This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a reduction, in the incidence of coronary events. This paper focuses on four major subjects: 1) the benefits of a lower blood pressure target during treatment; 2) the historical background of the "J-curve" phenomenon; 3) the evidence collected in recent clinical trials regarding the existence of a "J-curve" in treated hypertensive patients; and 4) the recent recommendations by the Task Force Committee of the European Society of Hypertension on blood pressure goals to be achieved during treatment.

Grassi, G., Quarti Trevano, F., Dell'Oro, R., & Mancia, G. (2010). The "J curve" problem revisited: old and new findings. CURRENT HYPERTENSION REPORTS, 12(4), 290-295 [10.1007/s11906-010-0121-7].

The "J curve" problem revisited: old and new findings

GRASSI, GUIDO
;
QUARTI TREVANO, FOSCA ANNA LUISA;DELL'ORO, RAFFAELLA;MANCIA, GIUSEPPE
2010

Abstract

This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a reduction, in the incidence of coronary events. This paper focuses on four major subjects: 1) the benefits of a lower blood pressure target during treatment; 2) the historical background of the "J-curve" phenomenon; 3) the evidence collected in recent clinical trials regarding the existence of a "J-curve" in treated hypertensive patients; and 4) the recent recommendations by the Task Force Committee of the European Society of Hypertension on blood pressure goals to be achieved during treatment.
No
Articolo in rivista - Articolo scientifico
Scientifica
Antihypertensive treatment; Blood pressure goals; Cardiovascular protection; Coronary artery disease; Guidelines; J-curve;
English
Grassi, G., Quarti Trevano, F., Dell'Oro, R., & Mancia, G. (2010). The "J curve" problem revisited: old and new findings. CURRENT HYPERTENSION REPORTS, 12(4), 290-295 [10.1007/s11906-010-0121-7].
Grassi, G; QUARTI TREVANO, F; Dell'Oro, R; Mancia, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/27058
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