This feature article describes chemoselective techniques for the assembly of neoglycopeptides and oligosaccharide mimics. Chemoselective ligation, allowing the use of aqueous environ- ments and non-protected substrates, provides rapid access to complex glycoconjugates. The role of these molecules in recognition, signal transduction pathways and other events of fundamental biomedical significance is an object of study in the emerging field of chemical glycomics.
Peri, F., Nicotra, F. (2004). Chemoselective Ligation in Glycochemistry. CHEMICAL COMMUNICATIONS, 4(6), 623-627 [10.1039/B308907J].
Chemoselective Ligation in Glycochemistry
PERI, FRANCESCO;NICOTRA, FRANCESCO
2004
Abstract
This feature article describes chemoselective techniques for the assembly of neoglycopeptides and oligosaccharide mimics. Chemoselective ligation, allowing the use of aqueous environ- ments and non-protected substrates, provides rapid access to complex glycoconjugates. The role of these molecules in recognition, signal transduction pathways and other events of fundamental biomedical significance is an object of study in the emerging field of chemical glycomics.
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