Suicide is a relevant worldwide public health problem. Many studies have shown that different demographic and clinical factors are potentially associated with suicidal behavior. Other studies have reported data about the role of biomarkers in the onset of suicidal behaviors. Specifically, researchers have found that suicidal risk may be increased by abnormalities in serotonergic system, hypothalamic-pituitary-adrenal axis, lipid metabolism, immune system and neuronal plasticity. The identification of specific biological parameters associated with self-harm may be helpful to implement prevention strategies and also to detect new therapeutic strategies. In this review, we summarize and analyze the results of main studies about neurobiological mechanisms related to suicidal behavior, also exploring the possible interconnection between the different biological systems.

Capuzzi, E., Caldiroli, A., Capellazzi, M., Tagliabue, I., Buoli, M., & Clerici, M. (2020). Biomarkers of suicidal behaviors: A comprehensive critical review. ADVANCES IN CLINICAL CHEMISTRY, 96, 179-216 [10.1016/bs.acc.2019.11.005].

Biomarkers of suicidal behaviors: A comprehensive critical review

Capuzzi E.
;
Capellazzi M.;Clerici M.
2020

Abstract

Suicide is a relevant worldwide public health problem. Many studies have shown that different demographic and clinical factors are potentially associated with suicidal behavior. Other studies have reported data about the role of biomarkers in the onset of suicidal behaviors. Specifically, researchers have found that suicidal risk may be increased by abnormalities in serotonergic system, hypothalamic-pituitary-adrenal axis, lipid metabolism, immune system and neuronal plasticity. The identification of specific biological parameters associated with self-harm may be helpful to implement prevention strategies and also to detect new therapeutic strategies. In this review, we summarize and analyze the results of main studies about neurobiological mechanisms related to suicidal behavior, also exploring the possible interconnection between the different biological systems.
Articolo in rivista - Review Essay
Scientifica
Biomarkers; Diathesis; Mental disorders; Model; Neurobiology; Risk factors; Suicidal behavior; Suicide;
English
Capuzzi, E., Caldiroli, A., Capellazzi, M., Tagliabue, I., Buoli, M., & Clerici, M. (2020). Biomarkers of suicidal behaviors: A comprehensive critical review. ADVANCES IN CLINICAL CHEMISTRY, 96, 179-216 [10.1016/bs.acc.2019.11.005].
Capuzzi, E; Caldiroli, A; Capellazzi, M; Tagliabue, I; Buoli, M; Clerici, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/268340
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