Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are the most common chronic cholestatic liver diseases (CLD) in adults and are associated with immune mechanisms. PBC is considered a model autoimmune disease, and more than 90% of patients present very specific autoantibodies against mitochondrial antigens. Whether PSC should be considered an autoimmune or merely immune-mediated disease is still under debate. This review addresses the clinical relevance of autoantibodies in CLD and their pathogenic mechanisms and illustrates the technology available for appropriate autoantibody detection.

Marzorati, S., Invernizzi, P., & Lleo, A. (2016). Making Sense of Autoantibodies in Cholestatic Liver Diseases. CLINICS IN LIVER DISEASE, 20(1), 33-46 [10.1016/j.cld.2015.08.003].

Making Sense of Autoantibodies in Cholestatic Liver Diseases

Invernizzi, Pietro;
2016

Abstract

Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are the most common chronic cholestatic liver diseases (CLD) in adults and are associated with immune mechanisms. PBC is considered a model autoimmune disease, and more than 90% of patients present very specific autoantibodies against mitochondrial antigens. Whether PSC should be considered an autoimmune or merely immune-mediated disease is still under debate. This review addresses the clinical relevance of autoantibodies in CLD and their pathogenic mechanisms and illustrates the technology available for appropriate autoantibody detection.
Articolo in rivista - Review Essay
Autoantibody; Biliary tree; Cholestatic diseases; Laboratory tools; Mitochondria; Nuclear proteins; Hepatology
English
33
46
14
Marzorati, S., Invernizzi, P., & Lleo, A. (2016). Making Sense of Autoantibodies in Cholestatic Liver Diseases. CLINICS IN LIVER DISEASE, 20(1), 33-46 [10.1016/j.cld.2015.08.003].
Marzorati, S; Invernizzi, P; Lleo, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/268259
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