Despite the different antineoplastic mechanisms of action, peripheral neurotoxicity induced by all chemotherapy drugs (anti-tubulin agents, platinum compounds, proteasome inhibitors, thalidomide) is associated with neuron morphological changes ascribable to cytoskeleton modifications. The “dying back” degeneration of distal terminals (sensory nerves) of dorsal root ganglia sensory neurons, observed in animal models, in in vitro cultures and biopsies of patients is the most evident hallmark of the perturbation of the cytoskeleton. On the other hand, in highly polarized cells like neurons, the cytoskeleton carries out its role not only in axons but also has a fundamental role in dendrite plasticity and in the organization of soma. In the literature, there are many studies focused on the antineoplastic-induced alteration of microtubule organization (and consequently, fast axonal transport defects) while very few studies have investigated the effect of the different classes of drugs on microfilaments, intermediate filaments and associated proteins. Therefore, in this review, we will focus on: (1) Highlighting the fundamental role of the crosstalk among the three filamentous subsystems and (2) investigating pivotal cytoskeleton-associated proteins.

Malacrida, A., Meregalli, C., Rodriguez Menendez, V., & Nicolini, G. (2019). Chemotherapy-induced peripheral neuropathy and changes in cytoskeleton. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(9) [10.3390/ijms20092287].

Chemotherapy-induced peripheral neuropathy and changes in cytoskeleton

Malacrida, A
Primo
;
Meregalli, C
Secondo
;
Rodriguez Menendez, V
Penultimo
;
Nicolini, G.
Ultimo
2019

Abstract

Despite the different antineoplastic mechanisms of action, peripheral neurotoxicity induced by all chemotherapy drugs (anti-tubulin agents, platinum compounds, proteasome inhibitors, thalidomide) is associated with neuron morphological changes ascribable to cytoskeleton modifications. The “dying back” degeneration of distal terminals (sensory nerves) of dorsal root ganglia sensory neurons, observed in animal models, in in vitro cultures and biopsies of patients is the most evident hallmark of the perturbation of the cytoskeleton. On the other hand, in highly polarized cells like neurons, the cytoskeleton carries out its role not only in axons but also has a fundamental role in dendrite plasticity and in the organization of soma. In the literature, there are many studies focused on the antineoplastic-induced alteration of microtubule organization (and consequently, fast axonal transport defects) while very few studies have investigated the effect of the different classes of drugs on microfilaments, intermediate filaments and associated proteins. Therefore, in this review, we will focus on: (1) Highlighting the fundamental role of the crosstalk among the three filamentous subsystems and (2) investigating pivotal cytoskeleton-associated proteins.
Articolo in rivista - Review Essay
Chemotherapy-induced-peripheral-neuropathy; Crosstalk; Cytoskeleton; Cytoskeleton-related proteins; Dorsal root ganglia; Microfilaments; Microtubules; Neurofilaments; Neurotoxicity;
chemotherapy-induced-peripheral-neuropathy; crosstalk; cytoskeleton; cytoskeleton-related proteins; dorsal root ganglia; microfilaments; microtubules; neurofilaments; neurotoxicity
English
Malacrida, A., Meregalli, C., Rodriguez Menendez, V., & Nicolini, G. (2019). Chemotherapy-induced peripheral neuropathy and changes in cytoskeleton. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(9) [10.3390/ijms20092287].
Malacrida, A; Meregalli, C; Rodriguez Menendez, V; Nicolini, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/267370
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