Primary cutaneous mucinous carcinomas originating from sweat glands are rare tumors with patterns of spread that are difficult to predict. We present a case of a five times recurring eccrine mucinous adenocarcinoma of the scalp, previously treated with surgery and adjuvant radiation therapy. After magnetic resonance imaging (MRI) and 18F-fluoro-2-deoxyglucose positron-emission tomography/computed tomography (18FDG-PET/CT), which documented local recurrence, the patient was considered eligible for salvage irradiation of the scalp. We decided to use helical tomotherapy, which combines conformity of dose delivery with the possibility of daily control of the setup accuracy. Forty gray (2Gy/fraction) to the planning target volume and 50 Gy (2.5Gy/fraction) to the biological target volume defined on the basis of 18FDG-PET/CT was prescribed with a simultaneous integrated boost technique. After 12 fractions the patient was submitted to intermediate evaluation by 18FDG-PET/CT, which showed a partial response to the treatment. After 2, 4, 8, and 12 months, 18FDG-PET/CT showed a complete metabolic local response. This experience suggests a possible role of 18FDG-PET/CT-guided helical tomotherapy as an alternative to repeated and frequently demolitive surgery approaches.

Motta, M., Alongi, F., De Martin, E., Fiorino, C., Maggiulli, E., Rigoni, L., et al. (2009). Helical tomotherapy for scalp recurrence of primary eccrine mucinous adenocarcinoma. TUMORI, 95(6), 832-835.

Helical tomotherapy for scalp recurrence of primary eccrine mucinous adenocarcinoma

LANDONI, CLAUDIO;
2009

Abstract

Primary cutaneous mucinous carcinomas originating from sweat glands are rare tumors with patterns of spread that are difficult to predict. We present a case of a five times recurring eccrine mucinous adenocarcinoma of the scalp, previously treated with surgery and adjuvant radiation therapy. After magnetic resonance imaging (MRI) and 18F-fluoro-2-deoxyglucose positron-emission tomography/computed tomography (18FDG-PET/CT), which documented local recurrence, the patient was considered eligible for salvage irradiation of the scalp. We decided to use helical tomotherapy, which combines conformity of dose delivery with the possibility of daily control of the setup accuracy. Forty gray (2Gy/fraction) to the planning target volume and 50 Gy (2.5Gy/fraction) to the biological target volume defined on the basis of 18FDG-PET/CT was prescribed with a simultaneous integrated boost technique. After 12 fractions the patient was submitted to intermediate evaluation by 18FDG-PET/CT, which showed a partial response to the treatment. After 2, 4, 8, and 12 months, 18FDG-PET/CT showed a complete metabolic local response. This experience suggests a possible role of 18FDG-PET/CT-guided helical tomotherapy as an alternative to repeated and frequently demolitive surgery approaches.
Articolo in rivista - Articolo scientifico
Tomography, X-Ray Computed; Tomography, Spiral Computed; Female; Neoplasm Recurrence, Local; Head and Neck Neoplasms; Salvage Therapy; Humans; Dose Fractionation; Positron-Emission Tomography; Adenocarcinoma, Mucinous; Aged; Scalp; Sweat Gland Neoplasms
English
832
835
Motta, M., Alongi, F., De Martin, E., Fiorino, C., Maggiulli, E., Rigoni, L., et al. (2009). Helical tomotherapy for scalp recurrence of primary eccrine mucinous adenocarcinoma. TUMORI, 95(6), 832-835.
Motta, M; Alongi, F; De Martin, E; Fiorino, C; Maggiulli, E; Rigoni, L; Landoni, C; Broggi, S; Deli, A; Calandrino, R; Di Muzio, N
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/26316
Citazioni
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
Social impact