A bicyclic scaffold derived from the natural monosaccharide D-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-30 position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.
Cervi, G., Peri, F., Gennari, C., Battistini, C., & Nicotra, F. (2006). Bicyclic carbohydrate-derived scaffolds for combinatorial libraries. BIOORGANIC & MEDICINAL CHEMISTRY, 14(10), 3349-3367.
Citazione: | Cervi, G., Peri, F., Gennari, C., Battistini, C., & Nicotra, F. (2006). Bicyclic carbohydrate-derived scaffolds for combinatorial libraries. BIOORGANIC & MEDICINAL CHEMISTRY, 14(10), 3349-3367. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Titolo: | Bicyclic carbohydrate-derived scaffolds for combinatorial libraries |
Autori: | Cervi, G; Peri, F; Gennari, C; Battistini, C; Nicotra, F |
Autori: | |
Data di pubblicazione: | 2006 |
Lingua: | English |
Rivista: | BIOORGANIC & MEDICINAL CHEMISTRY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.bmc.2005.12.055 |
Appare nelle tipologie: | 01 - Articolo su rivista |