A bicyclic scaffold derived from the natural monosaccharide D-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-30 position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.

Cervi, G., Peri, F., Gennari, C., Battistini, C., & Nicotra, F. (2006). Bicyclic carbohydrate-derived scaffolds for combinatorial libraries. BIOORGANIC & MEDICINAL CHEMISTRY, 14(10), 3349-3367 [10.1016/j.bmc.2005.12.055].

Bicyclic carbohydrate-derived scaffolds for combinatorial libraries

PERI, FRANCESCO;NICOTRA, FRANCESCO
2006

Abstract

A bicyclic scaffold derived from the natural monosaccharide D-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-30 position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.
Articolo in rivista - Articolo scientifico
Scientifica
combinatorial chemistry; carbohydrates; scaffolds
English
Cervi, G., Peri, F., Gennari, C., Battistini, C., & Nicotra, F. (2006). Bicyclic carbohydrate-derived scaffolds for combinatorial libraries. BIOORGANIC & MEDICINAL CHEMISTRY, 14(10), 3349-3367 [10.1016/j.bmc.2005.12.055].
Cervi, G; Peri, F; Gennari, C; Battistini, C; Nicotra, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/26305
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