A mimetic of Lipid A with a -N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its b-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflam- matory activity.
Peri, F., Marinzi, C., Barath, M., Granucci, F., Urbano, M., Nicotra, F. (2006). Synthesis and biological evaluation of novel lipid A antagonists. BIOORGANIC & MEDICINAL CHEMISTRY, 14(1), 190-199 [10.1016/j.bmc.2005.08.047].
Synthesis and biological evaluation of novel lipid A antagonists
PERI, FRANCESCO;GRANUCCI, FRANCESCA;URBANO, MATTEO;NICOTRA, FRANCESCO
2006
Abstract
A mimetic of Lipid A with a -N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its b-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflam- matory activity.
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