A mimetic of Lipid A with a -N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its b-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflam- matory activity.

Peri, F., Marinzi, C., Barath, M., Granucci, F., Urbano, M., & Nicotra, F. (2006). Synthesis and biological evaluation of novel Lipid A analogues. BIOORGANIC & MEDICINAL CHEMISTRY, 14(1), 190-199 [10.1016/j.bmc.2005.08.047].

Synthesis and biological evaluation of novel Lipid A analogues

PERI, FRANCESCO;GRANUCCI, FRANCESCA;URBANO, MATTEO;NICOTRA, FRANCESCO
2006

Abstract

A mimetic of Lipid A with a -N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its b-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflam- matory activity.
Articolo in rivista - Articolo scientifico
Scientifica
lipid A; medicinal chemistry; innate immunity; organic chemistry; sugars; carbohydrates
English
Peri, F., Marinzi, C., Barath, M., Granucci, F., Urbano, M., & Nicotra, F. (2006). Synthesis and biological evaluation of novel Lipid A analogues. BIOORGANIC & MEDICINAL CHEMISTRY, 14(1), 190-199 [10.1016/j.bmc.2005.08.047].
Peri, F; Marinzi, C; Barath, M; Granucci, F; Urbano, M; Nicotra, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/26302
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