The aims of this study were to assess the sensitivity of positron emission tomography (PET) using [18F]fluorodeoxyglucose (18F-FDG) in the detection of uveal melanoma, and to establish the relationship between pre-operative 18F-FDG uptake and a number of pathological features of uveal melanoma. Twenty consecutive patients with a clinical diagnosis of uveal melanoma were enrolled in the study. 18F-FDG uptake was assessed in all subjects and the following parameters were assessed in 11 enucleated subjects: the mitotic index, the MIB-1 proliferating cell index, number of epithelioid cells, largest tumour diameter, tumoral necrosis and inflammatory infiltration. Tumours with a diameter less than 7.5 mm were not detected by PET, possibly because of limited spatial resolution, and only 7 of 12 tumours with a diameter greater than 7.5 mm were detected. With tumours greater than 7.5 mm in diameter, PET and 18F-FDG allow two subgroups to be distinguished: those with high and those with low glucose consumption. Apart from tumour size, 18F-FDG uptake was not related to the pathological features examined. We hypothesize that 18F-FDG uptake may be related to the ratio of viable to non-viable cells, or to the hypoxic cell fraction within the tumour.
Modorati, G., Lucignani, G., Landoni, C., Freschi, M., Trabucchi, G., Fazio, F., et al. (1996). Glucose metabolism and pathological findings in uveal melanoma: preliminary results. NUCLEAR MEDICINE COMMUNICATIONS, 17(12), 1052-1056.
|Citazione:||Modorati, G., Lucignani, G., Landoni, C., Freschi, M., Trabucchi, G., Fazio, F., et al. (1996). Glucose metabolism and pathological findings in uveal melanoma: preliminary results. NUCLEAR MEDICINE COMMUNICATIONS, 17(12), 1052-1056.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Titolo:||Glucose metabolism and pathological findings in uveal melanoma: preliminary results|
|Autori:||Modorati, G; Lucignani, G; Landoni, C; Freschi, M; Trabucchi, G; Fazio, F; Brancato, R|
|Data di pubblicazione:||dic-1996|
|Rivista:||NUCLEAR MEDICINE COMMUNICATIONS|
|Appare nelle tipologie:||01 - Articolo su rivista|