The aims of this study were to assess the sensitivity of positron emission tomography (PET) using [18F]fluorodeoxyglucose (18F-FDG) in the detection of uveal melanoma, and to establish the relationship between pre-operative 18F-FDG uptake and a number of pathological features of uveal melanoma. Twenty consecutive patients with a clinical diagnosis of uveal melanoma were enrolled in the study. 18F-FDG uptake was assessed in all subjects and the following parameters were assessed in 11 enucleated subjects: the mitotic index, the MIB-1 proliferating cell index, number of epithelioid cells, largest tumour diameter, tumoral necrosis and inflammatory infiltration. Tumours with a diameter less than 7.5 mm were not detected by PET, possibly because of limited spatial resolution, and only 7 of 12 tumours with a diameter greater than 7.5 mm were detected. With tumours greater than 7.5 mm in diameter, PET and 18F-FDG allow two subgroups to be distinguished: those with high and those with low glucose consumption. Apart from tumour size, 18F-FDG uptake was not related to the pathological features examined. We hypothesize that 18F-FDG uptake may be related to the ratio of viable to non-viable cells, or to the hypoxic cell fraction within the tumour.

Modorati, G., Lucignani, G., Landoni, C., Freschi, M., Trabucchi, G., Fazio, F., et al. (1996). Glucose metabolism and pathological findings in uveal melanoma: preliminary results. NUCLEAR MEDICINE COMMUNICATIONS, 17(12), 1052-1056.

Glucose metabolism and pathological findings in uveal melanoma: preliminary results

LANDONI, CLAUDIO;FAZIO, FERRUCCIO;
1996-12

Abstract

The aims of this study were to assess the sensitivity of positron emission tomography (PET) using [18F]fluorodeoxyglucose (18F-FDG) in the detection of uveal melanoma, and to establish the relationship between pre-operative 18F-FDG uptake and a number of pathological features of uveal melanoma. Twenty consecutive patients with a clinical diagnosis of uveal melanoma were enrolled in the study. 18F-FDG uptake was assessed in all subjects and the following parameters were assessed in 11 enucleated subjects: the mitotic index, the MIB-1 proliferating cell index, number of epithelioid cells, largest tumour diameter, tumoral necrosis and inflammatory infiltration. Tumours with a diameter less than 7.5 mm were not detected by PET, possibly because of limited spatial resolution, and only 7 of 12 tumours with a diameter greater than 7.5 mm were detected. With tumours greater than 7.5 mm in diameter, PET and 18F-FDG allow two subgroups to be distinguished: those with high and those with low glucose consumption. Apart from tumour size, 18F-FDG uptake was not related to the pathological features examined. We hypothesize that 18F-FDG uptake may be related to the ratio of viable to non-viable cells, or to the hypoxic cell fraction within the tumour.
Articolo in rivista - Articolo scientifico
Scientifica
Sensitivity and Specificity; Glucose; Prognosis; Aged, 80 and over; Male; Fluorodeoxyglucose F18; Middle Aged; Female; Tomography, Emission-Computed; Uveal Neoplasms; Humans; Melanoma; Fluorine Radioisotopes; Deoxyglucose; Aged; Cell Division; Adult
English
Modorati, G., Lucignani, G., Landoni, C., Freschi, M., Trabucchi, G., Fazio, F., et al. (1996). Glucose metabolism and pathological findings in uveal melanoma: preliminary results. NUCLEAR MEDICINE COMMUNICATIONS, 17(12), 1052-1056.
Modorati, G; Lucignani, G; Landoni, C; Freschi, M; Trabucchi, G; Fazio, F; Brancato, R
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/26297
Citazioni
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 23
Social impact