High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02–1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30–1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63–0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Chang, C., La Vecchia, C., Serraino, D., Olshan, A., Zevallos, J., Morgenstern, H., et al. (2020). Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium. BRITISH JOURNAL OF CANCER, 122(6), 745-748 [10.1038/s41416-019-0702-4].

Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium

Garavello W.;
2020

Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02–1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30–1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63–0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.
Articolo in rivista - Articolo scientifico
Dietary glycaemic index, glycaemic load, head and neck cancer, risk
English
2020
122
6
745
748
none
Chang, C., La Vecchia, C., Serraino, D., Olshan, A., Zevallos, J., Morgenstern, H., et al. (2020). Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium. BRITISH JOURNAL OF CANCER, 122(6), 745-748 [10.1038/s41416-019-0702-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/262567
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