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Bicocca Open Archive
Background and objective: Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community-acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR-EB in a cohort of hospitalized adults with CAP. Methods: We performed a multinational, point-prevalence study of adult patients hospitalized with CAP. MDR-EB was defined when ≥3 antimicrobial classes were identified as non-susceptible. Risk factors assessment was also performed for patients with EB and MDR-EB infection. Results: Of the 3193 patients enrolled with CAP, 197 (6%) had a positive culture with EB. Fifty-one percent (n = 100) of EB were resistant to at least one antibiotic and 19% (n = 38) had MDR-EB. The most commonly EB identified were Klebsiella pneumoniae (n = 111, 56%) and Escherichia coli (n = 56, 28%). The risk factors that were independently associated with EB CAP were male gender, severe CAP, underweight (body mass index (BMI) < 18.5) and prior extended-spectrum beta-lactamase (ESBL) infection. Additionally, prior ESBL infection, being underweight, cardiovascular diseases and hospitalization in the last 12 months were independently associated with MDR-EB CAP. Conclusion: This study of adults hospitalized with CAP found a prevalence of EB of 6% and MDR-EB of 1.2%, respectively. The presence of specific risk factors, such as prior ESBL infection and being underweight, should raise the clinical suspicion for EB and MDR-EB in patients hospitalized with CAP.
Villafuerte, D., Aliberti, S., Soni, N., Faverio, P., Marcos, P., Wunderink, R., et al. (2020). Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia. RESPIROLOGY, 25(5 (May 2020)), 543-551 [10.1111/resp.13663].
Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia
Villafuerte D.;Aliberti S.;Soni N. J.;Faverio P.;Marcos P. J.;Wunderink R. G.;Rodriguez A.;Sibila O.;Sanz F.;Martin-Loeches I.;Menzella F.;Reyes L. F.;Jankovic M.;Spielmanns M.;Restrepo M. I.
;Aruj P. K.;Attorri S.;Barimboim E.;Caeiro J. P.;Garzon M. I.;Cambursano V. H.;Ceccato A.;Chertcoff J.;Cordon Diaz A.;de Vedia L.;Ganaha M. C.;Lambert S.;Lopardo G.;Luna C. M.;Malberti A. G.;Morcillo N.;Tartara S.;Pensotti C.;Pereyra B.;Scapellato P. G.;Stagnaro J. P.;Shah S.;Lotsch F.;Thalhammer F.;Anseeuw K.;Francois C. A.;Van Braeckel E.;Vincent J. L.;Djimon M. Z.;Nouer S. A.;Chipev P.;Encheva M.;Miteva D.;Petkova D.;Balkissou A. D.;Yone E. W. P.;Ngahane B. H. M.;Shen N.;Xu J. -F.;Rico C. A. B.;Buitrago R.;Paternina F. J. P.;Ntumba J. -M. K.;Carevic V. V.;Jakopovic M.;Jankovic M.;Matkovic Z.;Mitrecic I.;Jacobsson M. -L. B.;Christensen A. B.;Heitmann Bodtger U. C.;Meyer C. N.;Jensen A. V.;El-Said Abd El-Wahhab I.;Morsy N. E.;Shafiek H.;Sobh E.;Abdulsemed K. A.;Bertrand F.;Brun-Buisson C.;Montmollin E. D.;Fartoukh M.;Messika J.;Tattevin P.;Khoury A.;Ebruke B.;Dreher M.;Kolditz M.;Meisinger M.;Pletz M. W.;Hagel S.;Rupp J.;Schaberg T.;Spielmanns M.;Creutz P.;Suttorp N.;Siaw-Lartey B.;Dimakou K.;Papapetrou D.;Tsigou E.;Ampazis D.;Kaimakamis E.;Bhatia M.;Dhar R.;D'Souza G.;Garg R.;Koul P. A.;Mahesh P. A.;Jayaraj B. S.;Narayan K. V.;Udnur H. B.;Krishnamurthy S. B.;Kant S.;Swarnakar R.;Limaye S.;Salvi S.;Golshani K.;Keatings V. M.;Martin-Loeches I.;Maor Y.;Strahilevitz J.;Battaglia S.;Carrabba M.;Ceriana P.;Confalonieri M.;Monforte A. D.;Prato B. D.;Rosa M. D.;Fantini R.;Fiorentino G.;Gammino M. A.;Menzella F.;Milani G.;Nava S.;Palmiero G.;Petrino R.;Gabrielli B.;Rossi P.;Sorino C.;Steinhilber G.;Zanforlin A.;Franzetti F.;Carone M.;Patella V.;Scarlata S.;Comel A.;Kurahashi K.;Bacha Z. A.;Ugalde D. B.;Zuniga O. C.;Villegas J. F.;Medenica M.;van de Garde E. M. W.;Mihsra D. R.;Shrestha P.;Ridgeon E.;Awokola B. I.;Nwankwo O. N. O.;Olufunlola A. B.;Olumide S.;Ukwaja K. N.;Irfan M.;Minarowski L.;Szymon S.;Froes F.;Leuschner P.;Meireles M.;Ravara S. B.;Brocovschii V.;Ion C.;Rusu D.;Toma C.;Chirita D.;Dorobat C. M.;Birkun A.;Kaluzhenina A.;Almotairi A.;Bukhary Z. A. A.;Edathodu J.;Fathy A.;Enani A. M. A.;Mohamed N. E.;Memon J. U.;Bella A.;Bogdanovic N.;Milenkovic B.;Pesut D.;Borderias L.;Garcia N. M. B.;Cabello Alarcon H.;Cilloniz C.;Torres A.;Diaz-Brito V.;Casas X.;Gonzalez A. E.;Fernandez-Almira M. L.;Gallego M.;Gaspar-Garcia I.;Castillo J. G. D.;Victoria P. J.;Laserna Martinez E.;Molina R. M. D.;Marcos P. J.;Menendez R.;Pando-Sandoval A.;Aymerich C. P.;Rello J.;Moyano S.;Sanz F.;Sibila O.;Rodrigo-Troyano A.;Sole-Violan J.;Uranga A.;van Boven J. F. M.;Torra E. V.;Pujol J. A.;Feldman C.;Yum H. K.;Fiogbe A. A.;Yangui F.;Bilaceroglu S.;Dalar L.;Yilmaz U.;Bogomolov A.;Elahi N.;Dhasmana D. J.;Feneley A.;Hancock C.;Hill A. T.;Rudran B.;Ruiz-Buitrago S.;Campbell M.;Whitaker P.;Youzguin A.;Singanayagam A.;Allen K. S.;Brito V.;Dietz J.;Dysart C. E.;Kellie S. M.;Franco-Sadud R. A.;Meier G.;Gaga M.;Holland T. L.;Bergin S. P.;Kheir F.;Landmeier M.;Lois M.;Nair G. B.;Patel H.;Reyes K.;Rodriguez-Cintron W.;Saito S.;Soni N. J.;Noda J.;Hinojosa C. I.;Levine S. M.;Angel L. F.;Anzueto A.;Whitlow K. S.;Hipskind J.;Sukhija K.;Totten V.;Wunderink R. G.;Shah R. D.;Mateyo K. J.;Noriega L.;Alvarado E.;Aman M.;Labra L.
2020
Abstract
Background and objective: Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community-acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR-EB in a cohort of hospitalized adults with CAP. Methods: We performed a multinational, point-prevalence study of adult patients hospitalized with CAP. MDR-EB was defined when ≥3 antimicrobial classes were identified as non-susceptible. Risk factors assessment was also performed for patients with EB and MDR-EB infection. Results: Of the 3193 patients enrolled with CAP, 197 (6%) had a positive culture with EB. Fifty-one percent (n = 100) of EB were resistant to at least one antibiotic and 19% (n = 38) had MDR-EB. The most commonly EB identified were Klebsiella pneumoniae (n = 111, 56%) and Escherichia coli (n = 56, 28%). The risk factors that were independently associated with EB CAP were male gender, severe CAP, underweight (body mass index (BMI) < 18.5) and prior extended-spectrum beta-lactamase (ESBL) infection. Additionally, prior ESBL infection, being underweight, cardiovascular diseases and hospitalization in the last 12 months were independently associated with MDR-EB CAP. Conclusion: This study of adults hospitalized with CAP found a prevalence of EB of 6% and MDR-EB of 1.2%, respectively. The presence of specific risk factors, such as prior ESBL infection and being underweight, should raise the clinical suspicion for EB and MDR-EB in patients hospitalized with CAP.
Villafuerte, D., Aliberti, S., Soni, N., Faverio, P., Marcos, P., Wunderink, R., et al. (2020). Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia. RESPIROLOGY, 25(5 (May 2020)), 543-551 [10.1111/resp.13663].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/262298
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2021-2023 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 598/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
