"Signal alignments play critical roles in many clinical setting. This is the case of mass spectrometry (MS) data, an important component of many types of proteomic analysis. A central problem occurs when one needs to integrate (MS) data produced by different sources, e.g., different equipment and/or laboratories. In these cases, some form of "data integration or "data fusion may be necessary in order to discard some source-specific aspects and improve the ability to perform a classification task such as inferring the "disease classes of patients. The need for new high-performance data alignments methods is therefore particularly important in these contexts. In this paper, we propose an approach based both on an information theory perspective, generally used in a feature construction problem, and the application of a mathematical programming task (i.e., the weighted bipartite matching problem). We present the results of a competitive analysis of our method against other approaches. The analysis was conducted on data from plasma/ethylenediaminetetraacetic acid of "control and Alzheimer patients collected from three different hospitals. The results point to a significant performance advantage of our method with respect to the competing ones tested. © 2012 IEEE.
Zoppis, I.F., Gianazza, E., Borsani, M., Chinello, C., Mainini, V., Galbusera, C., et al. (2012). Mutual Information Optimization for Mass Spectra Data Alignment. IEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 9(3), 934-939 [10.1109/TCBB.2011.80].
|Citazione:||Zoppis, I.F., Gianazza, E., Borsani, M., Chinello, C., Mainini, V., Galbusera, C., et al. (2012). Mutual Information Optimization for Mass Spectra Data Alignment. IEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 9(3), 934-939 [10.1109/TCBB.2011.80].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Mutual Information Optimization for Mass Spectra Data Alignment|
|Autori:||Zoppis, IF; Gianazza, E; Borsani, M; Chinello, C; Mainini, V; Galbusera, C; Ferrarese, C; Galimberti, G; Sorbi, S; Borroni, B; Magni, F; Antoniotti, M; Mauri, G|
|Data di pubblicazione:||2012|
|Rivista:||IEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1109/TCBB.2011.80|
|Appare nelle tipologie:||01 - Articolo su rivista|