"Signal alignments play critical roles in many clinical setting. This is the case of mass spectrometry (MS) data, an important component of many types of proteomic analysis. A central problem occurs when one needs to integrate (MS) data produced by different sources, e.g., different equipment and/or laboratories. In these cases, some form of "data integration or "data fusion may be necessary in order to discard some source-specific aspects and improve the ability to perform a classification task such as inferring the "disease classes of patients. The need for new high-performance data alignments methods is therefore particularly important in these contexts. In this paper, we propose an approach based both on an information theory perspective, generally used in a feature construction problem, and the application of a mathematical programming task (i.e., the weighted bipartite matching problem). We present the results of a competitive analysis of our method against other approaches. The analysis was conducted on data from plasma/ethylenediaminetetraacetic acid of "control and Alzheimer patients collected from three different hospitals. The results point to a significant performance advantage of our method with respect to the competing ones tested. © 2012 IEEE.
Zoppis, I.F., Gianazza, E., Borsani, M., Chinello, C., Mainini, V., Galbusera, C., et al. (2012). Mutual Information Optimization for Mass Spectra Data Alignment. IEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 9(3), 934-939 [10.1109/TCBB.2011.80].
Citazione: | Zoppis, I.F., Gianazza, E., Borsani, M., Chinello, C., Mainini, V., Galbusera, C., et al. (2012). Mutual Information Optimization for Mass Spectra Data Alignment. IEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 9(3), 934-939 [10.1109/TCBB.2011.80]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Mutual Information Optimization for Mass Spectra Data Alignment | |
Autori: | Zoppis, IF; Gianazza, E; Borsani, M; Chinello, C; Mainini, V; Galbusera, C; Ferrarese, C; Galimberti, G; Sorbi, S; Borroni, B; Magni, F; Antoniotti, M; Mauri, G | |
Autori: | ||
Data di pubblicazione: | 2012 | |
Lingua: | English | |
Rivista: | IEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1109/TCBB.2011.80 | |
Appare nelle tipologie: | 01 - Articolo su rivista |