ObjectiveCauses of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures.MethodsWe prospectively analyzed a cohort of 41,638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs).ResultsWe identified 286 incident cases of Parkinson disease during follow-up. Multivariable adjusted hazard ratios were 1.06 (95% CI 0.76-1.47) for sitting time ≥6 vs <6 hours per day; and 1.13 (95% CI 0.60-2.12) for body mass index ≥30 vs <25 kg/m2. Results did not differ by sex.ConclusionsNo association between prolonged sitting time per day or obesity and risk of Parkinson disease was found.
Roos, E., Grotta, A., Yang, F., Bellocco, R., Ye, W., Adami, H., et al. (2018). Body mass index, sitting time, and risk of Parkinson disease. NEUROLOGY, 90(16), E1413-E1417 [10.1212/WNL.0000000000005328].
Body mass index, sitting time, and risk of Parkinson disease
Bellocco R.;
2018
Abstract
ObjectiveCauses of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures.MethodsWe prospectively analyzed a cohort of 41,638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs).ResultsWe identified 286 incident cases of Parkinson disease during follow-up. Multivariable adjusted hazard ratios were 1.06 (95% CI 0.76-1.47) for sitting time ≥6 vs <6 hours per day; and 1.13 (95% CI 0.60-2.12) for body mass index ≥30 vs <25 kg/m2. Results did not differ by sex.ConclusionsNo association between prolonged sitting time per day or obesity and risk of Parkinson disease was found.File | Dimensione | Formato | |
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