Background: Results from randomized trials of antioxidant supplementation have cast doubt on observational data linking diets high in antioxidants to a reduced risk of cardiovascular diseases. We hypothesized that supplementation of one or a few antioxidants might not simulate the complex actions of all antioxidants in the human diet. We therefore investigated the association between dietary Non Enzymatic Antioxidant Capacity (NEAC), reflecting the antioxidant potential of the whole diet, and the risk of myocardial infarction (MI). Methods: In the Swedish National March Cohort, 34 543 men and women free from cardiovascular diseases and cancer were followed through record linkages from 1997 until 2010. NEAC was assessed with a validated food-frequency questionnaire at baseline. The distribution of NEAC was categorized into sex-specific quartiles. We fitted multivariable Cox proportional hazards regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Results: During a mean follow-up time of 12.7 years, we identified 1142 incident cases of MI. Successively higher quartiles (Qs) of dietary NEAC were accompanied by a monotonic trend of decreasing MI incidence, both for overall MI (HR Q4 vs Q1: 0.77; 95% CI: 0.61–0.96; p for trend ¼ 0.008) and non-fatal MI (HR Q4 vs Q1: 0.72; 95% CI: 0.56–0.92; p for trend ¼ 0.004). No such association was found for fatal MI. Conclusions: A diet rich in antioxidants might protect from MI.

Hantikainen, E., Grotta, A., Serafini, M., Lagerros, Y., Nyren, O., Ye, W., et al. (2018). Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: The Swedish national March cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47(6), 1947-1955 [10.1093/ije/dyy220].

Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: The Swedish national March cohort

Hantikainen E.
;
Grotta A.;COLARUSSO, LUCA;Bellocco R.
2018

Abstract

Background: Results from randomized trials of antioxidant supplementation have cast doubt on observational data linking diets high in antioxidants to a reduced risk of cardiovascular diseases. We hypothesized that supplementation of one or a few antioxidants might not simulate the complex actions of all antioxidants in the human diet. We therefore investigated the association between dietary Non Enzymatic Antioxidant Capacity (NEAC), reflecting the antioxidant potential of the whole diet, and the risk of myocardial infarction (MI). Methods: In the Swedish National March Cohort, 34 543 men and women free from cardiovascular diseases and cancer were followed through record linkages from 1997 until 2010. NEAC was assessed with a validated food-frequency questionnaire at baseline. The distribution of NEAC was categorized into sex-specific quartiles. We fitted multivariable Cox proportional hazards regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Results: During a mean follow-up time of 12.7 years, we identified 1142 incident cases of MI. Successively higher quartiles (Qs) of dietary NEAC were accompanied by a monotonic trend of decreasing MI incidence, both for overall MI (HR Q4 vs Q1: 0.77; 95% CI: 0.61–0.96; p for trend ¼ 0.008) and non-fatal MI (HR Q4 vs Q1: 0.72; 95% CI: 0.56–0.92; p for trend ¼ 0.004). No such association was found for fatal MI. Conclusions: A diet rich in antioxidants might protect from MI.
Articolo in rivista - Articolo scientifico
Antioxidants; Atherosclerosis; Diet; Myocardial infarction; Non-enzymatic antioxidant capacity;
Antioxidants; Atherosclerosis; Diet; Myocardial infarction; Non-enzymatic antioxidant capacity; Adult; Aged; Antioxidants; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Proportional Hazards Models; Prospective Studies; Risk Factors; Sweden; Diet
English
2018
47
6
1947
1955
none
Hantikainen, E., Grotta, A., Serafini, M., Lagerros, Y., Nyren, O., Ye, W., et al. (2018). Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: The Swedish national March cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47(6), 1947-1955 [10.1093/ije/dyy220].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/261579
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