Thrombophilia, which severely impacts on morbidity and mortality of polycythaemia vera and essential thrombocythaemia, is variably characterized by microcirculatory disturbances, arterial and venous thromboses that often precede disease recognition. Thus, the search for Janus Kinase 2 mutation, the molecular marker of myeloproliferative neoplasms, is becoming increasingly common particularly in patients with vein thromboses at atypical sites. Although the pathogenesis of thrombophilia is still elusive, platelet and leukocyte abnormalities seem particularly critical and likely account for the antithrombotic efficacy of aspirin and hydroxyurea.

Landolfi, R., Di Gennaro, L., Falanga, A. (2008). Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation. LEUKEMIA, 22(11), 2020-2028 [10.1038/leu.2008.253].

Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation

Falanga A
2008

Abstract

Thrombophilia, which severely impacts on morbidity and mortality of polycythaemia vera and essential thrombocythaemia, is variably characterized by microcirculatory disturbances, arterial and venous thromboses that often precede disease recognition. Thus, the search for Janus Kinase 2 mutation, the molecular marker of myeloproliferative neoplasms, is becoming increasingly common particularly in patients with vein thromboses at atypical sites. Although the pathogenesis of thrombophilia is still elusive, platelet and leukocyte abnormalities seem particularly critical and likely account for the antithrombotic efficacy of aspirin and hydroxyurea.
Articolo in rivista - Review Essay
essential thrombocythaemia, polycythaemia vera, myeloproliferative disorders, thrombosis, JAK2
English
2008
22
11
2020
2028
none
Landolfi, R., Di Gennaro, L., Falanga, A. (2008). Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation. LEUKEMIA, 22(11), 2020-2028 [10.1038/leu.2008.253].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/259660
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