This study investigated whether the pre-surgical plasma levels of TAT and F1 + 2 of patients undergoing major surgery for localized tumours could identify patients at higher risk of thrombosis, and how heparin prophylaxis affected in vivo coagulation after cancer surgery. We measured the pre- and post-operative levels of TAT, F1 + 2, total factor VII (FVIIt) and zymogen FVII (FVIIz) in 117 cancer patients, with and without heparin prophylaxis. The end points of this study were DVT, initially detected by I-125-fibrinogen uptake test and confirmed by ascending venography. Pre-operative [TAT] and [F1 + 2] of the cancer patients were significantly higher than those of age-matched control subjects (n = 50) (P<0.005 and P<0.05, respectively); pre-operative [FVII] was not significantly different. One of the 83 patients receiving prophylaxis, and 8/34 not receiving prophylaxis developed post-operative DVT. Of the parameters evaluated, only the pre-operative [TAT]>3.5 ng/ml identified patients at higher risk for post-operative DVT. Heparin reduced plasma TAT levels and FVII consumption following surgery, suggesting that heparin modulates coagulation associated with cancer surgery. The results of this study also suggest that the pre-operative [TAT] may identify patients with higher risk for post-operative DVT

Falanga, A., Ofosu, F., Cortelazzo, S., Delaini, F., Consonni, R., Caccia, R., et al. (1993). Preliminary study to identify cancer patients at high risk of venous thrombosis following major surgery. BRITISH JOURNAL OF HAEMATOLOGY, 85(4), 745-750 [10.1111/j.1365-2141.1993.tb03218.x].

Preliminary study to identify cancer patients at high risk of venous thrombosis following major surgery

Falanga A;
1993

Abstract

This study investigated whether the pre-surgical plasma levels of TAT and F1 + 2 of patients undergoing major surgery for localized tumours could identify patients at higher risk of thrombosis, and how heparin prophylaxis affected in vivo coagulation after cancer surgery. We measured the pre- and post-operative levels of TAT, F1 + 2, total factor VII (FVIIt) and zymogen FVII (FVIIz) in 117 cancer patients, with and without heparin prophylaxis. The end points of this study were DVT, initially detected by I-125-fibrinogen uptake test and confirmed by ascending venography. Pre-operative [TAT] and [F1 + 2] of the cancer patients were significantly higher than those of age-matched control subjects (n = 50) (P<0.005 and P<0.05, respectively); pre-operative [FVII] was not significantly different. One of the 83 patients receiving prophylaxis, and 8/34 not receiving prophylaxis developed post-operative DVT. Of the parameters evaluated, only the pre-operative [TAT]>3.5 ng/ml identified patients at higher risk for post-operative DVT. Heparin reduced plasma TAT levels and FVII consumption following surgery, suggesting that heparin modulates coagulation associated with cancer surgery. The results of this study also suggest that the pre-operative [TAT] may identify patients with higher risk for post-operative DVT
Articolo in rivista - Articolo scientifico
high risk venous thrombosis surgery
English
745
750
6
Falanga, A., Ofosu, F., Cortelazzo, S., Delaini, F., Consonni, R., Caccia, R., et al. (1993). Preliminary study to identify cancer patients at high risk of venous thrombosis following major surgery. BRITISH JOURNAL OF HAEMATOLOGY, 85(4), 745-750 [10.1111/j.1365-2141.1993.tb03218.x].
Falanga, A; Ofosu, F; Cortelazzo, S; Delaini, F; Consonni, R; Caccia, R; Longatti, S; Maran, D; Rodeghiero, F; Pogliani, E; Marassi, A; D’Angelo, A; Barbui, T
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/259655
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