Cancer patients are highly susceptible to thromboembolic complications, which some have estimated accounts for a significant percentage of the morbidity and mortality of the disease. Not all of the mechanisms for the production of the hypercoagulable state characteristic of cancer are entirely understood. Those that are known seem to interdigitate the biology of cancer with the major regulatory pathways that mediate blood coagulation, platelet-vessel wall interaction, fibrinolysis and inflammatory cytokine production. In other words, the events responsible for thrombosis in cancer appears to be a result of an over exuberant host response in an attempt to delimit tumor growth. In this brief review, therefore, we attempt to put into the context of tumor growth, angiogenesis and metastasis the current information about the pathogenesis of venous thromboembolism (VTE). (C) 2001 Elsevier Science Ltd. All rights reserved

Rickles, F., & Falanga, A. (2001). Molecular basis for the relationship between thrombosis and cancer. THROMBOSIS RESEARCH, 102(6), V215-V224 [10.1016/S0049-3848(01)00285-7].

Molecular basis for the relationship between thrombosis and cancer

Falanga, A
2001

Abstract

Cancer patients are highly susceptible to thromboembolic complications, which some have estimated accounts for a significant percentage of the morbidity and mortality of the disease. Not all of the mechanisms for the production of the hypercoagulable state characteristic of cancer are entirely understood. Those that are known seem to interdigitate the biology of cancer with the major regulatory pathways that mediate blood coagulation, platelet-vessel wall interaction, fibrinolysis and inflammatory cytokine production. In other words, the events responsible for thrombosis in cancer appears to be a result of an over exuberant host response in an attempt to delimit tumor growth. In this brief review, therefore, we attempt to put into the context of tumor growth, angiogenesis and metastasis the current information about the pathogenesis of venous thromboembolism (VTE). (C) 2001 Elsevier Science Ltd. All rights reserved
Articolo in rivista - Articolo scientifico
CancerThromboembolismProcoagulantsFibrinolysisCytokinesAngiogenesis
English
V215
V224
Rickles, F., & Falanga, A. (2001). Molecular basis for the relationship between thrombosis and cancer. THROMBOSIS RESEARCH, 102(6), V215-V224 [10.1016/S0049-3848(01)00285-7].
Rickles, F; Falanga, A
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/259641
Citazioni
  • Scopus 298
  • ???jsp.display-item.citation.isi??? 262
Social impact