Objective: To assess the efficacy of intravenous immunoglobulin (IVIG), in comparison with plasma exchange (PE), in the treatment of patients with thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). Design: Prospective, nonrandomized comparative study. Setting: Hematology department in a general hospital. Patients: 17 consecutive adult patients, six of them pregnant, with diagnosis of TTP/HUS. Three had a severity score at diagnosis less-than-or-equal-to 4 and were treated with IVIG and 14 had a severity score of greater-than-or-equal-to 5 and/or were pregnant and received PE. The response was evaluated after 5 days of therapy. Results: Complete remission was obtained in 0/3 cases treated with IVIG and 10/14 (71%) with PE (Fisher's exact test P = 0.05). Three patients died for widespread TTP-HUS, and four had persistent disease. In three of the four resistant patients, complete remission was obtained by further PE but not by further IVIG. The overall remission rate was 76% (13/17). Conclusions: Our study does not confirm the utility of IVIG in the management of TTP-HUS, as suggested by earlier single case reports

Finazzi, G., Bellavita, P., Falanga, A., Viero, P., Barbui, T. (1992). INEFFICACY OF INTRAVENOUS IMMUNOGLOBULIN IN PATIENTS WITH LOW-RISK THROMBOTIC THROMBOCYTOPENIC PURPURA/HEMOLYTIC-UREMIC SYNDROME. AMERICAN JOURNAL OF HEMATOLOGY, 41(3), 165-169 [10.1002/ajh.2830410305].

INEFFICACY OF INTRAVENOUS IMMUNOGLOBULIN IN PATIENTS WITH LOW-RISK THROMBOTIC THROMBOCYTOPENIC PURPURA/HEMOLYTIC-UREMIC SYNDROME

Falanga, A;
1992

Abstract

Objective: To assess the efficacy of intravenous immunoglobulin (IVIG), in comparison with plasma exchange (PE), in the treatment of patients with thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). Design: Prospective, nonrandomized comparative study. Setting: Hematology department in a general hospital. Patients: 17 consecutive adult patients, six of them pregnant, with diagnosis of TTP/HUS. Three had a severity score at diagnosis less-than-or-equal-to 4 and were treated with IVIG and 14 had a severity score of greater-than-or-equal-to 5 and/or were pregnant and received PE. The response was evaluated after 5 days of therapy. Results: Complete remission was obtained in 0/3 cases treated with IVIG and 10/14 (71%) with PE (Fisher's exact test P = 0.05). Three patients died for widespread TTP-HUS, and four had persistent disease. In three of the four resistant patients, complete remission was obtained by further PE but not by further IVIG. The overall remission rate was 76% (13/17). Conclusions: Our study does not confirm the utility of IVIG in the management of TTP-HUS, as suggested by earlier single case reports
Articolo in rivista - Articolo scientifico
thrombotic thrombocytopenic purpura/hemolytic‐uremic syndrome
English
1992
41
3
165
169
none
Finazzi, G., Bellavita, P., Falanga, A., Viero, P., Barbui, T. (1992). INEFFICACY OF INTRAVENOUS IMMUNOGLOBULIN IN PATIENTS WITH LOW-RISK THROMBOTIC THROMBOCYTOPENIC PURPURA/HEMOLYTIC-UREMIC SYNDROME. AMERICAN JOURNAL OF HEMATOLOGY, 41(3), 165-169 [10.1002/ajh.2830410305].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/259633
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