Several fungi secrete lipase isozymes differing in biochemical properties and in some cases in substrate specificity. In the yeast Candida rugosa, a family of related genes encodes for multiple lipase proteins, highly homologous in sequence but partially different in the regions interacting with the substrate molecule. Analysis of these substitutions performed on the basis of multiple alignments and using a 3-D model of the enzyme, allows identification of a restricted number of amino adds possibly involved in substrate specificity of Candida lipases. © 1994 Oxford University Press.
Lotti, M., Tramontano, A., Longhi, S., Fusetti, F., Brocca, S., Pizzi, E., et al. (1994). Variability within the Candida rugosa upases family. PROTEIN ENGINEERING, 7(4), 531-535 [10.1093/protein/7.4.531].
Variability within the Candida rugosa upases family
Lotti M.;Brocca S.;Alberghina L.
1994
Abstract
Several fungi secrete lipase isozymes differing in biochemical properties and in some cases in substrate specificity. In the yeast Candida rugosa, a family of related genes encodes for multiple lipase proteins, highly homologous in sequence but partially different in the regions interacting with the substrate molecule. Analysis of these substitutions performed on the basis of multiple alignments and using a 3-D model of the enzyme, allows identification of a restricted number of amino adds possibly involved in substrate specificity of Candida lipases. © 1994 Oxford University Press.
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