Purpose: To assess whether changes in diffusionweighted MRI (DW-MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA). Materials and Methods: Seventeen patients underwent both DW-MRI and 18F-FDG-PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC-SUVBW-mean) were evaluated and compared with histopathological TRG. Results: Pre- And post-NT and percentage changes forADC and PVC-SUVBW-mean were assessed. Post-NT ADC and DADC showed a significant inverse correlation with TRG (r=-0.71; P=0.0011 and r=-0.78; P=0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1-2-3) and nonresponders (TRG 4-5) (P=0.0009; P=0.000082, respectively). No correlations with TRG were found for pre-NT ADC and for all PVC-SUVBW-mean values as well as between DADC and D PVC-SUVBW-mean. Conclusion: DW-MRI seems more accurate than 18FFDG-PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA
Giganti, F., De Cobelli, F., Canevari, C., Orsenigo, E., Gallivanone, F., Esposito, A., et al. (2014). Response to chemotherapy in gastric adenocarcinoma with diffusion-weighted MRI and 18F-FDG-PET/CT: Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade. JOURNAL OF MAGNETIC RESONANCE IMAGING, 40(5), 1147-1157 [10.1002/jmri.24464].
Response to chemotherapy in gastric adenocarcinoma with diffusion-weighted MRI and 18F-FDG-PET/CT: Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade
CASTIGLIONI I;
2014
Abstract
Purpose: To assess whether changes in diffusionweighted MRI (DW-MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA). Materials and Methods: Seventeen patients underwent both DW-MRI and 18F-FDG-PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC-SUVBW-mean) were evaluated and compared with histopathological TRG. Results: Pre- And post-NT and percentage changes forADC and PVC-SUVBW-mean were assessed. Post-NT ADC and DADC showed a significant inverse correlation with TRG (r=-0.71; P=0.0011 and r=-0.78; P=0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1-2-3) and nonresponders (TRG 4-5) (P=0.0009; P=0.000082, respectively). No correlations with TRG were found for pre-NT ADC and for all PVC-SUVBW-mean values as well as between DADC and D PVC-SUVBW-mean. Conclusion: DW-MRI seems more accurate than 18FFDG-PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GAI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.