Naming abilities are typically preserved in amnestic Mild Cognitive Impairment (aMCI), a condition associated with increased risk of progression to Alzheimer's disease (AD). We compared the functional correlates of covert picture naming and word reading between a group of aMCI subjects and matched controls. Unimpaired picture naming performance was associated with more extensive activations, in particular involving the parietal lobes, in the aMCI group. In addition, in the condition associated with higher processing demands (blocks of categorically homogeneous items, living items), increased activity was observed in the aMCI group, in particular in the left fusiform gyrus. Graph analysis provided further evidence of increased modularity and reduced integration for the homogenous sets in the aMCI group. The functional modifications associated with preserved performance may reflect, in the case of more demanding tasks, compensatory mechanisms for the subclinical involvement of semantic processing areas by AD pathology.

Catricalà, E., Della Rosa, P., Parisi, L., Zippo, A., Borsa, V., Iadanza, A., et al. (2015). Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment. NEUROPSYCHOLOGIA, 76, 136-152 [10.1016/j.neuropsychologia.2015.01.009].

Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment

CASTIGLIONI I;
2015

Abstract

Naming abilities are typically preserved in amnestic Mild Cognitive Impairment (aMCI), a condition associated with increased risk of progression to Alzheimer's disease (AD). We compared the functional correlates of covert picture naming and word reading between a group of aMCI subjects and matched controls. Unimpaired picture naming performance was associated with more extensive activations, in particular involving the parietal lobes, in the aMCI group. In addition, in the condition associated with higher processing demands (blocks of categorically homogeneous items, living items), increased activity was observed in the aMCI group, in particular in the left fusiform gyrus. Graph analysis provided further evidence of increased modularity and reduced integration for the homogenous sets in the aMCI group. The functional modifications associated with preserved performance may reflect, in the case of more demanding tasks, compensatory mechanisms for the subclinical involvement of semantic processing areas by AD pathology.
Articolo in rivista - Articolo scientifico
MRI
English
2015
76
136
152
none
Catricalà, E., Della Rosa, P., Parisi, L., Zippo, A., Borsa, V., Iadanza, A., et al. (2015). Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment. NEUROPSYCHOLOGIA, 76, 136-152 [10.1016/j.neuropsychologia.2015.01.009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/257578
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