An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins. © 2011 Elsevier Ltd. All rights reserved.
Russo, L., Landi, E., Tampieri, A., Natalello, A., Doglia, S., Gabrielli, L., et al. (2011). Sugar-decorated hydroxyapatite: an inorganic material bioactivated with carbohydrates. CARBOHYDRATE RESEARCH, 346(12), 1564-1568 [10.1016/j.carres.2011.04.044].
Sugar-decorated hydroxyapatite: an inorganic material bioactivated with carbohydrates
RUSSO, LAURA;NATALELLO, ANTONINO;DOGLIA, SILVIA MARIA;GABRIELLI, LUCA;CIPOLLA, LAURA FRANCESCA;NICOTRA, FRANCESCO
2011
Abstract
An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins. © 2011 Elsevier Ltd. All rights reserved.
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