Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described

Grandi, S., Cassinelli, V., Bini, M., Saino, E., Mustarelli, P., Arciola, C., et al. (2011). Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 34(9), 920-928 [10.5301/ijao.5000059].

Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties

Mustarelli, P;
2011

Abstract

Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described
Articolo in rivista - Articolo scientifico
Scaffolds, bones
English
2011
34
9
920
928
reserved
Grandi, S., Cassinelli, V., Bini, M., Saino, E., Mustarelli, P., Arciola, C., et al. (2011). Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 34(9), 920-928 [10.5301/ijao.5000059].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/256971
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