Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-λ receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-λ. Here, we discuss recent findings that establish the unique capacity of IFN-λ to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges

Broggi, A., Granucci, F., & Zanoni, I. (2020). Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion. JOURNAL OF EXPERIMENTAL MEDICINE, 217(1) [10.1084/jem.20190295].

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

Broggi, A
Membro del Collaboration Group
;
Granucci, F
Membro del Collaboration Group
;
Zanoni, I
2020

Abstract

Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-λ receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-λ. Here, we discuss recent findings that establish the unique capacity of IFN-λ to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges
Si
Articolo in rivista - Review Essay
Scientifica
type III interferons
English
Broggi, A., Granucci, F., & Zanoni, I. (2020). Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion. JOURNAL OF EXPERIMENTAL MEDICINE, 217(1) [10.1084/jem.20190295].
Broggi, A; Granucci, F; Zanoni, I
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/255572
Citazioni
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 54
Social impact