Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-λ receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-λ. Here, we discuss recent findings that establish the unique capacity of IFN-λ to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges

Broggi, A., Granucci, F., Zanoni, I. (2020). Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion. JOURNAL OF EXPERIMENTAL MEDICINE, 217(1) [10.1084/jem.20190295].

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

Broggi, A
Membro del Collaboration Group
;
Granucci, F
Membro del Collaboration Group
;
Zanoni, I
2020

Abstract

Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-λ receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-λ. Here, we discuss recent findings that establish the unique capacity of IFN-λ to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges
Articolo in rivista - Review Essay
type III interferons
English
Broggi, A., Granucci, F., Zanoni, I. (2020). Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion. JOURNAL OF EXPERIMENTAL MEDICINE, 217(1) [10.1084/jem.20190295].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/255572
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