Background Radiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas. Methods Online databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity. Results The estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%–98.9% and 53.1%–97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%. Conclusions RS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.

Pinzi, V., Biagioli, E., Roberto, A., Galli, F., Rizzi, M., Chiappa, F., et al. (2017). Radiosurgery for intracranial meningiomas: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 113, 122-134 [10.1016/j.critrevonc.2017.03.005].

Radiosurgery for intracranial meningiomas: A systematic review and meta-analysis

Pinzi V.
Primo
;
Galli F.;Brenna G.;
2017

Abstract

Background Radiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas. Methods Online databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity. Results The estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%–98.9% and 53.1%–97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%. Conclusions RS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.
Articolo in rivista - Review Essay
Hypo-fractionated stereotactic radiotherapy; Intracranial meningioma; Radiosurgery; Staged radiosurgery; WHO I meningioma; WHO II meningioma; Adolescent; Adult; Aged; Aged, 80 and over; Child; Disease-Free Survival; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Radiation Injuries; Radiosurgery; Treatment Outcome; Young Adult
English
2017
113
122
134
none
Pinzi, V., Biagioli, E., Roberto, A., Galli, F., Rizzi, M., Chiappa, F., et al. (2017). Radiosurgery for intracranial meningiomas: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 113, 122-134 [10.1016/j.critrevonc.2017.03.005].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/255102
Citazioni
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 30
Social impact