Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes. The response and/or adaptation to hypoxia and other changing environmental conditions can influence the properties and functions of membranes by modifying lipid composition. In the yeast Kluyveromyces lactis, the KlMga2 gene is a hypoxic regulatory factor for lipid biosynthesis-fatty acids and sterols- A nd is also involved in glucose signaling, glucose catabolism and is generally important for cellular fitness. In this work we show that, in addition to the above defects, the absence of the KlMGA2 gene caused increased resistance to oxidative stress and extended lifespan of the yeast, associated with increased expression levels of catalase and SOD genes. We propose that KlMga2 might also act as a mediator of the oxidative stress response/adaptation, thus revealing connections among hypoxia, glucose signaling, fatty acid biosynthesis and ROS metabolism in K. lactis.

Santomartino, R., Camponeschi, I., Polo, G., Immesi, A., Rinaldi, T., Mazzoni, C., et al. (2019). The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis. FEMS YEAST RESEARCH, 19(3) [10.1093/femsyr/foz020].

The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis

Brambilla L.;
2019

Abstract

Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes. The response and/or adaptation to hypoxia and other changing environmental conditions can influence the properties and functions of membranes by modifying lipid composition. In the yeast Kluyveromyces lactis, the KlMga2 gene is a hypoxic regulatory factor for lipid biosynthesis-fatty acids and sterols- A nd is also involved in glucose signaling, glucose catabolism and is generally important for cellular fitness. In this work we show that, in addition to the above defects, the absence of the KlMGA2 gene caused increased resistance to oxidative stress and extended lifespan of the yeast, associated with increased expression levels of catalase and SOD genes. We propose that KlMga2 might also act as a mediator of the oxidative stress response/adaptation, thus revealing connections among hypoxia, glucose signaling, fatty acid biosynthesis and ROS metabolism in K. lactis.
Articolo in rivista - Articolo scientifico
catalase; fatty acids; life span; lipid droplets; ROS; superoxide dismutase; Adaptation, Physiological; Catalase; Fatty Acids; Fungal Proteins; Gene Expression Regulation; Glucose; Hypoxia; Kluyveromyces; Membrane Proteins; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Transcription Factors; Oxidative Stress
English
2019
19
3
foz020
reserved
Santomartino, R., Camponeschi, I., Polo, G., Immesi, A., Rinaldi, T., Mazzoni, C., et al. (2019). The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis. FEMS YEAST RESEARCH, 19(3) [10.1093/femsyr/foz020].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/254793
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