Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety profile and still inspire the ongoing investigations. However, several restrictions, such as high manufacturing costs, technical challenges, and effectiveness below expectations, raised skeptical opinions within the scientific community about the clinical relevance of nanomedicine. In this review, we aim to give an overall vision of the current hurdles encountered by nanotherapeutics along with their design, development, and translation, and we offer a prospective view on possible strategies to overcome such limitations

Salvioni, L., Rizzuto, M., Bertolini, J., Pandolfi, L., Colombo, M., Prosperi, D. (2019). Thirty years of cancer nanomedicine: Success, frustration, and hope. CANCERS, 11(12) [10.3390/cancers11121855].

Thirty years of cancer nanomedicine: Success, frustration, and hope

Salvioni L.
Primo
;
Rizzuto M. A.
;
Bertolini J. A.
;
Colombo M.
;
Prosperi D.
Ultimo
2019

Abstract

Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety profile and still inspire the ongoing investigations. However, several restrictions, such as high manufacturing costs, technical challenges, and effectiveness below expectations, raised skeptical opinions within the scientific community about the clinical relevance of nanomedicine. In this review, we aim to give an overall vision of the current hurdles encountered by nanotherapeutics along with their design, development, and translation, and we offer a prospective view on possible strategies to overcome such limitations
Articolo in rivista - Review Essay
EPR effect; cancer nanomedicine; clinical translation; nanoparticles; nano–bio interactions; tumor microenvironment
English
2019
11
12
1855
partially_open
Salvioni, L., Rizzuto, M., Bertolini, J., Pandolfi, L., Colombo, M., Prosperi, D. (2019). Thirty years of cancer nanomedicine: Success, frustration, and hope. CANCERS, 11(12) [10.3390/cancers11121855].
File in questo prodotto:
File Dimensione Formato  
10281-254392.pdf

accesso aperto

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 1.24 MB
Formato Adobe PDF
1.24 MB Adobe PDF Visualizza/Apri
Colombo-M_7.pdf

Solo gestori archivio

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 1.25 MB
Formato Adobe PDF
1.25 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/254392
Citazioni
  • Scopus 136
  • ???jsp.display-item.citation.isi??? 121
Social impact