Amyotrophic lateral sclerosis (ALS) patients often express cognitive and behavioral dysfunctions within the so-called “frontotemporal spectrum disorders.” Guidelines recommend screening of such dysfunctions, albeit only ALS dedicated tools are eventually suitable, due to the profound motor limitations induced by the disease. ALS Cognitive Behavioral Screen (ALS-CBS) is such a screening tool but normative data are not available, limiting its widespread implementation. Our aim consisted in producing normative data for the Italian version of the ALS-CBS. The scale was administered to n = 458 healthy controls with different age and education. Following translation and back translation of the original version of the test, normative data and correction scores for the ALS-CBS cognitive subtest (ALS-CBSci) were generated. Furthermore, n = 100 ALS consecutive outpatients with a wide range of cognitive and motor severity underwent to the ALS-CBS, besides FAB and Weigl sorting test (WST), in order to check its usability. Completion rate was 100% for ALS-CBS and WST, and 68% for the FAB. Corrected ALS-CBS scores showed 12% detection rate of significant cognitive dysfunction with a moderate kappa with FAB and WST. For the ALS-CBS behavioral subtest (ALS-CBSbi), a caregiver was available for n = 81 ALS patients and asked to complete the subset. The detection rate for behavioral dysfunction was 55.5%, and a mild correlation between with the Caregiver Burden Inventory was present (r = − 0.26, p = 0.04). In conclusion, we offer here normative data for the ALS-CBS, a handy tool for screening frontotemporal spectrum dysfunctions in ALS patients, and confirm its usability and validity in an outpatient setting.
Tremolizzo, L., Lizio, A., Santangelo, G., Diamanti, S., Lunetta, C., Gerardi, F., et al. (2020). ALS Cognitive Behavioral Screen (ALS-CBS): normative values for the Italian population and clinical usability. NEUROLOGICAL SCIENCES, 41(4), 835-841.
|Citazione:||Tremolizzo, L., Lizio, A., Santangelo, G., Diamanti, S., Lunetta, C., Gerardi, F., et al. (2020). ALS Cognitive Behavioral Screen (ALS-CBS): normative values for the Italian population and clinical usability. NEUROLOGICAL SCIENCES, 41(4), 835-841.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||ALS Cognitive Behavioral Screen (ALS-CBS): normative values for the Italian population and clinical usability|
|Autori:||Tremolizzo, L; Lizio, A; Santangelo, G; Diamanti, S; Lunetta, C; Gerardi, F; Messina, S; La Foresta, S; Riva, N; Falzone, Y; Filippi, M; Woolley, S; Sansone, V; Siciliano, M; Ferrarese, C; Appollonio, I; Sala, G|
TREMOLIZZO, LUCIO (Corresponding)
SALA, GESSICA [Membro del Collaboration Group]
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10072-019-04154-1|
|Appare nelle tipologie:||01 - Articolo su rivista|