IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
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EnglishTo investigate ventilator-induced lung injury (VILI), several experimental models were designed including different mammalian species and ventilator settings, leading to a large variability in the observed time-course and injury severity. We hypothesized that the time-course of VILI may be fully explained from a single perspective when considering the insult actually applied, i.e. lung stress and strain. METHODS: Studies in which healthy animals were aggressively ventilated until preterminal VILI were selected via a Medline search. Data on morphometry, ventilator settings, respiratory function and duration of ventilation were derived. For each animal group, lung stress(transpulmonary pressure) and strain (end-inspiratory lung inflation/lung resting volume ratio)were estimated. RESULTS: From the Medline search 20 studies including five mammalian species (sheep, pigs, rabbits, rats, mice) were selected. Time to achieve preterminal VILI varied widely (18-2,784 min), did not correlate with either tidal volume (expressed in relation to body weight) or airway pressure applied, but was weakly associated with lung stress (r (2) = 0.25, p = 0.008). In contrast, the duration of mechanical ventilation was closely correlated with both lung strain (r (2) = 0.85, p < 0.0001) and lung strain weighted for the actual time of application during each breath (r (2) = 0.83, p <0.0001), according to exponential decay functions. When it was normalized for the lung strain applied, larger species showed a greater resistance to VILI than smaller species (medians, 25th-75th percentiles: 690, 460-2,001 min vs. 16, 4-59 min, respectively; p < 0.001). CONCLUSION: Lung strain may play a critical role as a unifying rule describing the development of VILI among mammals with healthy lungs
Caironi, P., Langer, T., Carlesso, E., Protti, A., & Gattinoni, L. (2011). Time to generate ventilator-induced lung injury among mammals with healthy lungs : a unifying hypothesis. INTENSIVE CARE MEDICINE, 37(12), 1913-1920 [10.1007/s00134-011-2388-9].
| Citazione: | Caironi, P., Langer, T., Carlesso, E., Protti, A., & Gattinoni, L. (2011). Time to generate ventilator-induced lung injury among mammals with healthy lungs : a unifying hypothesis. INTENSIVE CARE MEDICINE, 37(12), 1913-1920 [10.1007/s00134-011-2388-9]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Time to generate ventilator-induced lung injury among mammals with healthy lungs : a unifying hypothesis | |
| Autori: | Caironi, P; Langer, T; Carlesso, E; Protti, A; Gattinoni, L | |
| Autori: | ||
| Data di pubblicazione: | 2011 | |
| Lingua: | English | |
| Rivista: | INTENSIVE CARE MEDICINE | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00134-011-2388-9 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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