In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has more recently been investigated and characterized in the specific context of social experiences across several mammalian species. Accordingly, the present narrative review provides a comprehensive summary of studies detailing how the opioid system controls social reward and social pain. From a translational and pathophysiological perspective, we further discuss how opioid-dependent regulation of social behaviors may contribute to depressive illness and suicidal behaviors, and ultimately provide innovative therapeutic opportunities.

Lutz, P., Courtet, P., Calati, R. (2020). The opioid system and the social brain: implications for depression and suicide. JOURNAL OF NEUROSCIENCE RESEARCH, 98(4), 588-600 [10.1002/jnr.24269].

The opioid system and the social brain: implications for depression and suicide

Calati, R
2020

Abstract

In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has more recently been investigated and characterized in the specific context of social experiences across several mammalian species. Accordingly, the present narrative review provides a comprehensive summary of studies detailing how the opioid system controls social reward and social pain. From a translational and pathophysiological perspective, we further discuss how opioid-dependent regulation of social behaviors may contribute to depressive illness and suicidal behaviors, and ultimately provide innovative therapeutic opportunities.
Articolo in rivista - Review Essay
depression; Opioid system; social pain; social reward; suicide;
English
26-lug-2018
2020
98
4
588
600
none
Lutz, P., Courtet, P., Calati, R. (2020). The opioid system and the social brain: implications for depression and suicide. JOURNAL OF NEUROSCIENCE RESEARCH, 98(4), 588-600 [10.1002/jnr.24269].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/249925
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