Objective: The management of treatment-resistant depression is a much debated issue. In particular, the evidence supporting the commonly suggested sequential use of antidepressants from 2 different pharmacological classes is weak.This retrospective study was undertaken to investigate whether there is a better response in nonresponders switched to a different class of antidepressants (across-class) compared with nonresponders switched to an antidepressant from the same class (within-class). Methods: Three hundred forty patients with primary major depressive disorder were recruited in the context of a European multicenter project. Subjects whose current depressive episode had failed to respond to a first antidepressant trial of adequate dose and duration were included. Results: There was no significant difference in response or remission rates between the across-class and within-class groups after controlling for possible confounders. Conclusions: In depressed nonresponders to a previous antidepressant treatment, switching to a different class of antidepressants was not associated with a better response or remission rate. © 2011 Lippincott Williams & Wilkins.

Souery, D., Serretti, A., Calati, R., Oswald, P., Massat, I., Konstantinidis, A., et al. (2011). Switching Antidepressant Class Does Not Improve Response or Remission in Treatment-Resistant Depression. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 31(4), 512-516 [10.1097/JCP.0b013e3182228619].

Switching Antidepressant Class Does Not Improve Response or Remission in Treatment-Resistant Depression

Calati R;
2011

Abstract

Objective: The management of treatment-resistant depression is a much debated issue. In particular, the evidence supporting the commonly suggested sequential use of antidepressants from 2 different pharmacological classes is weak.This retrospective study was undertaken to investigate whether there is a better response in nonresponders switched to a different class of antidepressants (across-class) compared with nonresponders switched to an antidepressant from the same class (within-class). Methods: Three hundred forty patients with primary major depressive disorder were recruited in the context of a European multicenter project. Subjects whose current depressive episode had failed to respond to a first antidepressant trial of adequate dose and duration were included. Results: There was no significant difference in response or remission rates between the across-class and within-class groups after controlling for possible confounders. Conclusions: In depressed nonresponders to a previous antidepressant treatment, switching to a different class of antidepressants was not associated with a better response or remission rate. © 2011 Lippincott Williams & Wilkins.
Articolo in rivista - Articolo scientifico
major depression; antidepressant; resistant depression; pharmacotherapy
English
2011
31
4
512
516
none
Souery, D., Serretti, A., Calati, R., Oswald, P., Massat, I., Konstantinidis, A., et al. (2011). Switching Antidepressant Class Does Not Improve Response or Remission in Treatment-Resistant Depression. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 31(4), 512-516 [10.1097/JCP.0b013e3182228619].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/249214
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