Alzheimer's disease (AD) is a major world health problem and it is the major cause of dementia in the elderly. It is characterized by a progressive deterioration in memory, cognitive and behavioral aspects. A number of different genes are possibly involved in AD: 4 were confirmed in several studies, while at least 50 additional genes were tested with contrasting results. The final aim of genetic studies is the identification of the genes involved in AD, to understand the biological mechanism of this disease and, consequently, to develop appropriate treatments. The aim of this review is to explore the genetic characteristics of AD, from a detailed etiologic hypothesis about the disease to the suggestion of possible involved genes, and underline the need of further studies
Serretti, A., Calati, R., Artioli, P., De Ronchi, D. (2006). Genetic aspects of Alzheimer’s Disease: state of the art and research. MINERVA PSICHIATRICA, 47(1), 35-58.
Genetic aspects of Alzheimer’s Disease: state of the art and research
Calati, R;
2006
Abstract
Alzheimer's disease (AD) is a major world health problem and it is the major cause of dementia in the elderly. It is characterized by a progressive deterioration in memory, cognitive and behavioral aspects. A number of different genes are possibly involved in AD: 4 were confirmed in several studies, while at least 50 additional genes were tested with contrasting results. The final aim of genetic studies is the identification of the genes involved in AD, to understand the biological mechanism of this disease and, consequently, to develop appropriate treatments. The aim of this review is to explore the genetic characteristics of AD, from a detailed etiologic hypothesis about the disease to the suggestion of possible involved genes, and underline the need of further studies
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
