The paper investigates the problem of tracking a desired plasma glucose evolution by means of intra-venous insulin administration. A model-based approach is followed. Only measurements of glycemia are considered. A nonlinear observer for delay differential systems is used for the estimation of insulinemia. In the spirit of the separation theorem, a nonlinear control law is proposed, based on the feedback linearization, which makes use of the observer estimations instead of the full state measurements. The local convergence of the tracking error to zero is theoretically proved. In silico simulations, which also take into account input saturation, show the very good performance of the proposed control technique.

Palumbo, P., Pepe, P., Panunzi, S., De Gaetano, A. (2009). Observer-based closed-loop control of plasma glycemia. In Proceedings 48th IEEE Conference on Decision and Control (CDC09) (pp.3507-3512). Institute of Electrical and Electronics Engineers Inc. [10.1109/CDC.2009.5400805].

Observer-based closed-loop control of plasma glycemia

Palumbo, P;
2009

Abstract

The paper investigates the problem of tracking a desired plasma glucose evolution by means of intra-venous insulin administration. A model-based approach is followed. Only measurements of glycemia are considered. A nonlinear observer for delay differential systems is used for the estimation of insulinemia. In the spirit of the separation theorem, a nonlinear control law is proposed, based on the feedback linearization, which makes use of the observer estimations instead of the full state measurements. The local convergence of the tracking error to zero is theoretically proved. In silico simulations, which also take into account input saturation, show the very good performance of the proposed control technique.
paper
Blood-glucose control; Input-output linearization; Nonlinear delay systems
English
48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009
2009
Proceedings 48th IEEE Conference on Decision and Control (CDC09)
9781424438716
2009
3507
3512
5400805
http://www.nt.ntnu.no/users/skoge/prost/proceedings/cdc09/data/papers/2504.pdf
reserved
Palumbo, P., Pepe, P., Panunzi, S., De Gaetano, A. (2009). Observer-based closed-loop control of plasma glycemia. In Proceedings 48th IEEE Conference on Decision and Control (CDC09) (pp.3507-3512). Institute of Electrical and Electronics Engineers Inc. [10.1109/CDC.2009.5400805].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/246624
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