The Euglycemic Hyperinsulinemic Clamp (EHC) is considered the gold standard experiment for the determination of insulin sensitivity. It consists of a nontrivial perturbation experiment, during which large amounts of insulin are administered intra-venously to the subject, and exogenous glucose is administered, according to given protocols, in order to keep glycemia constant. This note proposes a closed-loop glucose control methodology for the EHC. A Delay Differential Equation (DDE) model of the EHC is considered to synthesize the control law. The use of an observer for nonlinear DDE systems allows the use of only glucose measurements in order to design the feedback (instead of insulin measurements, which are less accurate, more expensive and more cumbersome to obtain). The main result consists in the proof of convergence of the observer estimate error in case of a piecewise-constant control, which is what occurs in practice by intermittent manual regulation of the glucose infusion pump. Numerical results show the effectiveness of the proposed methodology

Palumbo, P., Pepe, P., Panunzi, S., De Gaetano, A. (2013). Closed-loop glucose control: application to the Euglycemic Hyperinsulinemic Clamp. In Proc. 52nd Conference of Decision and Control (CDC13) (pp.4461-4466) [10.1109/CDC.2013.6760576].

Closed-loop glucose control: application to the Euglycemic Hyperinsulinemic Clamp

Palumbo, P;
2013

Abstract

The Euglycemic Hyperinsulinemic Clamp (EHC) is considered the gold standard experiment for the determination of insulin sensitivity. It consists of a nontrivial perturbation experiment, during which large amounts of insulin are administered intra-venously to the subject, and exogenous glucose is administered, according to given protocols, in order to keep glycemia constant. This note proposes a closed-loop glucose control methodology for the EHC. A Delay Differential Equation (DDE) model of the EHC is considered to synthesize the control law. The use of an observer for nonlinear DDE systems allows the use of only glucose measurements in order to design the feedback (instead of insulin measurements, which are less accurate, more expensive and more cumbersome to obtain). The main result consists in the proof of convergence of the observer estimate error in case of a piecewise-constant control, which is what occurs in practice by intermittent manual regulation of the glucose infusion pump. Numerical results show the effectiveness of the proposed methodology
paper
Glucose control; Glucose-insulin modeling; Time-delay systems
English
Conference of Decision and Control (CDC13) 10-13 December
2013
Proc. 52nd Conference of Decision and Control (CDC13)
978-146735717-3
2013
4461
4466
6760576
reserved
Palumbo, P., Pepe, P., Panunzi, S., De Gaetano, A. (2013). Closed-loop glucose control: application to the Euglycemic Hyperinsulinemic Clamp. In Proc. 52nd Conference of Decision and Control (CDC13) (pp.4461-4466) [10.1109/CDC.2013.6760576].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/246593
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