This note investigates the problem of plasma glucose regulation by means of subcutaneous insulin administration. A discrete delay dierential equation model of the glucoseinsulin regulatory system has been considered, which properly takes into account also the pancreatic insulin release, in such a way to allow insulin therapies for both Type I and Type II diabetes (in this latter case the endogenous insulin delivery is not negligible). The method of exact input/output feedback linearization and stabilization is used, in order to ensure the local convergence of the tracking error to zero. Simulations are performed in a virtual environment, and numerical results show the eectiveness of the proposed approach.
Palumbo, P., Pepe, P., Panunzi, S., De Gaetano, A. (2011). Glucose control by subcutaneous insulin administration: a DDE modelling approach. In 18th IFAC World Congress on Automatic Control (IFAC2011) (pp.1471-1476). IFAC Secretariat [10.3182/20110828-6-IT-1002.01374].
Glucose control by subcutaneous insulin administration: a DDE modelling approach
Palumbo, P;
2011
Abstract
This note investigates the problem of plasma glucose regulation by means of subcutaneous insulin administration. A discrete delay dierential equation model of the glucoseinsulin regulatory system has been considered, which properly takes into account also the pancreatic insulin release, in such a way to allow insulin therapies for both Type I and Type II diabetes (in this latter case the endogenous insulin delivery is not negligible). The method of exact input/output feedback linearization and stabilization is used, in order to ensure the local convergence of the tracking error to zero. Simulations are performed in a virtual environment, and numerical results show the eectiveness of the proposed approach.File | Dimensione | Formato | |
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2011-08 IFAC-Milano - Glucose control by subcutaneous insulin administration.pdf
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