Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits. © 2011 Elsevier B.V..

Airoldi, C., Zona, C., Sironi, E., Colombo, L., Messa, M., Aurilia, D., et al. (2011). Curcumin derivatives as new ligands of Aβ peptides. JOURNAL OF BIOTECHNOLOGY, 156(4), 317-324 [10.1016/j.jbiotec.2011.07.021].

Curcumin derivatives as new ligands of Aβ peptides

AIROLDI, CRISTINA;ZONA, CRISTIANO;SIRONI, ERIKA;GREGORI, MARIA;MASSERINI, MASSIMO ERNESTO;NICOTRA, FRANCESCO;LA FERLA, BARBARA
2011

Abstract

Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits. © 2011 Elsevier B.V..
Articolo in rivista - Articolo scientifico
Alzheimer’s disease, Abeta peptides, Abeta ligands, Curcumin derivatives, NMR interaction studies, Conformational analysis, Brain amyloid plaque staining
English
2011
156
4
317
324
none
Airoldi, C., Zona, C., Sironi, E., Colombo, L., Messa, M., Aurilia, D., et al. (2011). Curcumin derivatives as new ligands of Aβ peptides. JOURNAL OF BIOTECHNOLOGY, 156(4), 317-324 [10.1016/j.jbiotec.2011.07.021].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/24572
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