Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits. © 2011 Elsevier B.V..
Airoldi, C., Zona, C., Sironi, E., Colombo, L., Messa, M., Aurilia, D., et al. (2011). Curcumin derivatives as new ligands of Aβ peptides. JOURNAL OF BIOTECHNOLOGY, 156(4), 317-324 [10.1016/j.jbiotec.2011.07.021].
Curcumin derivatives as new ligands of Aβ peptides
AIROLDI, CRISTINA;ZONA, CRISTIANO;SIRONI, ERIKA;GREGORI, MARIA;MASSERINI, MASSIMO ERNESTO;NICOTRA, FRANCESCO;LA FERLA, BARBARA
2011
Abstract
Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits. © 2011 Elsevier B.V..
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