Purpose: Status Epilepticus can be a serious life threatening event in epileptic patients. The definition of refractory or super-refractory Status Epilepticus was based on the therapeutic response to anti-epileptic and anesthetic drugs. Vagal Nerve Stimulation showed efficacy in treating drug-resistant epilepsy but there are only few reports on emergentplacement of Vagal Nerve Stimulator for refractory or super-refractory Status Epilepticus. Methods: Among 49 children implanted at our Institution with Vagal Nerve Stimulation for drug-resistant epilepsy, the authors retrospectively identified those implanted for refractory or super-refractory Status Epilepticus, according with the current definitions. Results: 4 patients were operated upon at ages ranging 7 to 17 months and reached the programmed output current of 1 mA over a time ranging from 24 to 36 h (fast ramping-up). In 3 out of 4 patient we observed the abrupt of Status Epilepticus; one patient was refractory both to drugs and Vagal Nerve Stimulation and later died, without recovering from SE. At follow up, ranging from 24 to 45 months, the remaining 3 patients showed a decrease of the seizures frequency >80% without relapse of Status Epilepticus; in all the patients, output current and/or Duty Cycle were increased later. Conclusion: VNS can be effective in treating refractory or super-refractory Status Epilepticus.

Grioni, D., Landi, A., Fiori, L., Sganzerla, E. (2018). Does emergent implantation of a vagal nerve stimulator stop refractory status epilepticus in children?. SEIZURE, 61, 94-97 [10.1016/j.seizure.2018.08.008].

Does emergent implantation of a vagal nerve stimulator stop refractory status epilepticus in children?

Sganzerla, EP
2018

Abstract

Purpose: Status Epilepticus can be a serious life threatening event in epileptic patients. The definition of refractory or super-refractory Status Epilepticus was based on the therapeutic response to anti-epileptic and anesthetic drugs. Vagal Nerve Stimulation showed efficacy in treating drug-resistant epilepsy but there are only few reports on emergentplacement of Vagal Nerve Stimulator for refractory or super-refractory Status Epilepticus. Methods: Among 49 children implanted at our Institution with Vagal Nerve Stimulation for drug-resistant epilepsy, the authors retrospectively identified those implanted for refractory or super-refractory Status Epilepticus, according with the current definitions. Results: 4 patients were operated upon at ages ranging 7 to 17 months and reached the programmed output current of 1 mA over a time ranging from 24 to 36 h (fast ramping-up). In 3 out of 4 patient we observed the abrupt of Status Epilepticus; one patient was refractory both to drugs and Vagal Nerve Stimulation and later died, without recovering from SE. At follow up, ranging from 24 to 45 months, the remaining 3 patients showed a decrease of the seizures frequency >80% without relapse of Status Epilepticus; in all the patients, output current and/or Duty Cycle were increased later. Conclusion: VNS can be effective in treating refractory or super-refractory Status Epilepticus.
Articolo in rivista - Articolo scientifico
Childhood; Status epilepticus; Vagal nerve stimulation;
Childhood; Status epilepticus; Vagal nerve stimulation; Adolescent; Anticonvulsants; Brain Waves; Child; Child, Preschool; Drug Resistant Epilepsy; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Male; Retrospective Studies; Status Epilepticus; Treatment Outcome; Vagus Nerve Stimulation; Electrodes, Implanted
English
2018
61
94
97
open
Grioni, D., Landi, A., Fiori, L., Sganzerla, E. (2018). Does emergent implantation of a vagal nerve stimulator stop refractory status epilepticus in children?. SEIZURE, 61, 94-97 [10.1016/j.seizure.2018.08.008].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/244962
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