Background/Aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma. Patients and Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39.1%) patients had squamous cell carcinoma, five (21.7%) had a thyroid carcinoma, six (26.1%) had a carcinoid, one (4.3%) patient had papillary renal carcinoma, one (4.3%) had medulloblastoma and one (4.3%) had intestinal-type mucinous adenocarcinoma. Results: All six patients with stage I squamous cell carcinoma had no evidence of disease (NED) after a median time of 141 months. Of the three patients with stage IIb-IIIc squamous cell carcinoma, two had NED after 119 and 154 months, and one died of the disease 9 months after diagnosis. All five women with stage I thyroid carcinoma had NED after a median of 60 months. Of the six patients with stage I carcinoid, five had NED after a median of 168 months, whereas one died due to carcinoid heart disease. The three patients with stage I renal carcinoma, medulloblastoma and mucinous adenocarcinoma had NED after 24, 141 and 149 months, respectively. Conclusion: The clinical outcome of early-stage malignancies associated with mature ovarian teratomas is excellent following treatment.

Gadducci, A., Giuliani, D., Cosio, S., Lissoni, A., Ferrero, A., Landoni, F. (2019). Clinical outcome of patients with malignant tumors associated with mature cystic teratomas of the ovary: A retrospective multicenter Italian study. ANTICANCER RESEARCH, 39(5), 2513-2517 [10.21873/anticanres.13372].

Clinical outcome of patients with malignant tumors associated with mature cystic teratomas of the ovary: A retrospective multicenter Italian study

Giuliani, D;Lissoni, A;Landoni, F
2019

Abstract

Background/Aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma. Patients and Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39.1%) patients had squamous cell carcinoma, five (21.7%) had a thyroid carcinoma, six (26.1%) had a carcinoid, one (4.3%) patient had papillary renal carcinoma, one (4.3%) had medulloblastoma and one (4.3%) had intestinal-type mucinous adenocarcinoma. Results: All six patients with stage I squamous cell carcinoma had no evidence of disease (NED) after a median time of 141 months. Of the three patients with stage IIb-IIIc squamous cell carcinoma, two had NED after 119 and 154 months, and one died of the disease 9 months after diagnosis. All five women with stage I thyroid carcinoma had NED after a median of 60 months. Of the six patients with stage I carcinoid, five had NED after a median of 168 months, whereas one died due to carcinoid heart disease. The three patients with stage I renal carcinoma, medulloblastoma and mucinous adenocarcinoma had NED after 24, 141 and 149 months, respectively. Conclusion: The clinical outcome of early-stage malignancies associated with mature ovarian teratomas is excellent following treatment.
Articolo in rivista - Articolo scientifico
Carcinoid; Mature cystic teratoma; Squamous cell carcinoma; Surgery; Thyroid carcinoma;
Carcinoid; Mature cystic teratoma; Squamous cell carcinoma; Surgery; Thyroid carcinoma; Adult; Aged; Carcinoid Tumor; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Female; Humans; Medulloblastoma; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Retrospective Studies; Teratoma; Thyroid Neoplasms
English
2513
2517
5
Gadducci, A., Giuliani, D., Cosio, S., Lissoni, A., Ferrero, A., Landoni, F. (2019). Clinical outcome of patients with malignant tumors associated with mature cystic teratomas of the ovary: A retrospective multicenter Italian study. ANTICANCER RESEARCH, 39(5), 2513-2517 [10.21873/anticanres.13372].
Gadducci, A; Giuliani, D; Cosio, S; Lissoni, A; Ferrero, A; Landoni, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/244637
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