Growth hormone secretagogues (GHS) are a family of synthetic molecules, first discovered in the late 1970s for their ability to stimulate growth hormone (GH) release. Many effects of GHS are mediated by binding to GHS-R1a, the receptor for the endogenous hormone ghrelin, a 28-amino acid peptide isolated from the stomach. Besides endocrine functions, both ghrelin and GHS are endowed with some relevant extraendocrine properties, including stimulation of food intake, anticonvulsant and anti-inflammatory effects, and protection of muscle tissue in different pathological conditions. In particular, ghrelin and GHS inhibit cardiomyocyte and endothelial cell apoptosis and improve cardiac left ventricular function during ischemia-reperfusion injury. Moreover, in a model of cisplatin-induced cachexia, GHS protect skeletal muscle from mitochondrial damage and improve lean mass recovery. Most of these effects are mediated by GHS ability to preserve intracellular Ca2+ homeostasis. In this review, we address the muscle-specific protective effects of GHS mediated by Ca2+ regulation, but also highlight recent findings of their therapeutic potential in pathological conditions characterized by skeletal or cardiac muscle impairment.

Bresciani, E., Rizzi, L., Coco, S., Molteni, L., Meanti, R., Locatelli, V., et al. (2019). Growth hormone secretagogues and the regulation of calcium signaling in muscle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(18) [10.3390/ijms20184361].

Growth hormone secretagogues and the regulation of calcium signaling in muscle

Bresciani, Elena;Rizzi, Laura;Coco, Silvia;Molteni, Laura;Meanti, Ramona;Locatelli, Vittorio;Torsello, Antonio
2019

Abstract

Growth hormone secretagogues (GHS) are a family of synthetic molecules, first discovered in the late 1970s for their ability to stimulate growth hormone (GH) release. Many effects of GHS are mediated by binding to GHS-R1a, the receptor for the endogenous hormone ghrelin, a 28-amino acid peptide isolated from the stomach. Besides endocrine functions, both ghrelin and GHS are endowed with some relevant extraendocrine properties, including stimulation of food intake, anticonvulsant and anti-inflammatory effects, and protection of muscle tissue in different pathological conditions. In particular, ghrelin and GHS inhibit cardiomyocyte and endothelial cell apoptosis and improve cardiac left ventricular function during ischemia-reperfusion injury. Moreover, in a model of cisplatin-induced cachexia, GHS protect skeletal muscle from mitochondrial damage and improve lean mass recovery. Most of these effects are mediated by GHS ability to preserve intracellular Ca2+ homeostasis. In this review, we address the muscle-specific protective effects of GHS mediated by Ca2+ regulation, but also highlight recent findings of their therapeutic potential in pathological conditions characterized by skeletal or cardiac muscle impairment.
Articolo in rivista - Review Essay
Cachexia; Calcium (ca; 2+; ) homeostasis; Cardiac ischemia/reperfusion (i/r) damage; GHS (growth hormone secretagogues); Skeletal muscle wasting;
GHS (growth hormone secretagogues); cachexia; calcium (Ca2+) homeostasis; cardiac ischemia/reperfusion (I/R) damage; skeletal muscle wasting
English
Bresciani, E., Rizzi, L., Coco, S., Molteni, L., Meanti, R., Locatelli, V., et al. (2019). Growth hormone secretagogues and the regulation of calcium signaling in muscle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(18) [10.3390/ijms20184361].
Bresciani, E; Rizzi, L; Coco, S; Molteni, L; Meanti, R; Locatelli, V; Torsello, A
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