We aimed at clarifying the strength and consistency of the association between cannabis use disorder and suicide attempts in bipolar disorder. We conducted a systematic review and meta-analysis of observational studies providing cross-sectional and longitudinal data on this association. We screened articles indexed in Medline, Embase, PsycINFO databases up to July 2018. The random-effects meta-analysis, based on 6375 subjects from eleven studies, estimated a cross-sectional association between cannabis use disorder and history of suicide attempts (OR = 1.35; p = 0.01; I2 = 41.7%). Meta-regression analyses showed that effect size was not influenced by any study characteristics. Publication bias was not detectable. We could not perform a meta-analysis exploring the longitudinal association between cannabis use disorder and suicide attempts, due to the lack of suitable data. The current evidence highlights a weak association between cannabis use disorder and suicidal attempts in bipolar disorder. Due to the cross-sectional design of included studies, causal inferences could not be explored.

Bartoli, F., Crocamo, C., Carra, G. (2019). Cannabis use disorder and suicide attempts in bipolar disorder: A meta-analysis. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 103, 14-20 [10.1016/j.neubiorev.2019.05.017].

Cannabis use disorder and suicide attempts in bipolar disorder: A meta-analysis

Bartoli, F;Crocamo, C;Carra, G
2019

Abstract

We aimed at clarifying the strength and consistency of the association between cannabis use disorder and suicide attempts in bipolar disorder. We conducted a systematic review and meta-analysis of observational studies providing cross-sectional and longitudinal data on this association. We screened articles indexed in Medline, Embase, PsycINFO databases up to July 2018. The random-effects meta-analysis, based on 6375 subjects from eleven studies, estimated a cross-sectional association between cannabis use disorder and history of suicide attempts (OR = 1.35; p = 0.01; I2 = 41.7%). Meta-regression analyses showed that effect size was not influenced by any study characteristics. Publication bias was not detectable. We could not perform a meta-analysis exploring the longitudinal association between cannabis use disorder and suicide attempts, due to the lack of suitable data. The current evidence highlights a weak association between cannabis use disorder and suicidal attempts in bipolar disorder. Due to the cross-sectional design of included studies, causal inferences could not be explored.
Articolo in rivista - Articolo scientifico
Bipolar disorder; Cannabis; Meta-analysis; Suicide;
English
2019
103
14
20
reserved
Bartoli, F., Crocamo, C., Carra, G. (2019). Cannabis use disorder and suicide attempts in bipolar disorder: A meta-analysis. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 103, 14-20 [10.1016/j.neubiorev.2019.05.017].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/241479
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