Sympathetic neural activation occurs in congestive heart failure (CHF). However, the small sample size of the microneurographic studies, heterogeneity of the patients examined, presence of comorbidities as well as confounders (including treatment) represented major weaknesses not allowing to identify the major features of the phoenomenon, particularly in mild CHF. This meta-analysis evaluated 2530 heart failure (CHF) patients recruited in 106 microneurographic studies. It was based on muscle sympathetic nerve activity (MSNA) quantification in CHF of different clinical severity, but data from less widely addressed conditions, such as ischemic vs. idiopathic, were also considered.
Grassi, G., D'Arrigo, G., Pisano, A., Bolignano, D., Mallamaci, F., Dell'Oro, R., et al. (2019). Sympathetic neural overdrive in congestive heart failure and its correlates: systematic reviews and meta-analysis. JOURNAL OF HYPERTENSION, 37(9), 1746-1756 [10.1097/HJH.0000000000002093].
Sympathetic neural overdrive in congestive heart failure and its correlates: systematic reviews and meta-analysis
Grassi, G
;Dell'Oro, R;Quarti-Trevano, F;Mancia, G;
2019
Abstract
Sympathetic neural activation occurs in congestive heart failure (CHF). However, the small sample size of the microneurographic studies, heterogeneity of the patients examined, presence of comorbidities as well as confounders (including treatment) represented major weaknesses not allowing to identify the major features of the phoenomenon, particularly in mild CHF. This meta-analysis evaluated 2530 heart failure (CHF) patients recruited in 106 microneurographic studies. It was based on muscle sympathetic nerve activity (MSNA) quantification in CHF of different clinical severity, but data from less widely addressed conditions, such as ischemic vs. idiopathic, were also considered.
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