BACKGROUND: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤1 drink per day), 0.90 for moderate (1 to <4 drinks per day), and 1.16 for heavy (≥4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was <1 up to 70 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.

Tramacere, I., Pelucchi, C., Bagnardi, V., Rota, M., Scotti, L., Islami, F., et al. (2012). A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. ANNALS OF ONCOLOGY, 23(2), 287-297 [10.1093/annonc/mdr136].

A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk

BAGNARDI, VINCENZO;ROTA, MATTEO;SCOTTI, LORENZA;CORRAO, GIOVANNI;
2012

Abstract

BACKGROUND: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤1 drink per day), 0.90 for moderate (1 to <4 drinks per day), and 1.16 for heavy (≥4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was <1 up to 70 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.
Articolo in rivista - Articolo scientifico
alcohol drinking; dose–risk relation; esophageal and gastric cardia adenocarcinomas; meta-analysis; systematic review
English
287
297
11
Tramacere, I., Pelucchi, C., Bagnardi, V., Rota, M., Scotti, L., Islami, F., et al. (2012). A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. ANNALS OF ONCOLOGY, 23(2), 287-297 [10.1093/annonc/mdr136].
Tramacere, I; Pelucchi, C; Bagnardi, V; Rota, M; Scotti, L; Islami, F; Corrao, G; Boffetta, P; La Vecchia, C; Negri, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/23376
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