We aimed to perform a systematic review and meta-analysis of appetite regulating hormones in patients with first-episode psychosis (FEP). Meta-analyses were conducted using random-effects models with Hedges’ g as the effect size estimate. We identified 31 eligible studies, investigating the levels of 7 appetite regulating hormones (adiponectin, insulin, leptin, ghrelin, orexin, resistin and visfatin) in 1792 FEP patients and 1364 controls. The insulin levels in FEP patients were higher than in controls (g = 0.34, 95%CI: 0.19 – 0.49, p < 0.001), even considering only antipsychotic-naïve patients (g = 0.39, 95%CI: 0.12 – 0.66, p = 0.005). The severity of negative symptoms was positively associated with the effect size estimates (β = 0.08, 95%CI: 0.01 – 0.16, p = 0.030). Moreover, we found lower levels of leptin in antipsychotic-naïve FEP patients (g = -0.62, 95%CI: -1.11 – 0.12, p = 0.015). Impaired appetite regulation, in terms of elevated insulin levels and decreased leptin levels, occurs in early psychosis, before antipsychotic treatment. Hyperinsulinemia might be related to negative symptoms.

Misiak, B., Bartoli, F., Stramecki, F., Samochowiec, J., Lis, M., Kasznia, J., et al. (2019). Appetite regulating hormones in first-episode psychosis: A systematic review and meta-analysis. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 102, 362-370 [10.1016/j.neubiorev.2019.05.018].

Appetite regulating hormones in first-episode psychosis: A systematic review and meta-analysis

Bartoli, F;
2019

Abstract

We aimed to perform a systematic review and meta-analysis of appetite regulating hormones in patients with first-episode psychosis (FEP). Meta-analyses were conducted using random-effects models with Hedges’ g as the effect size estimate. We identified 31 eligible studies, investigating the levels of 7 appetite regulating hormones (adiponectin, insulin, leptin, ghrelin, orexin, resistin and visfatin) in 1792 FEP patients and 1364 controls. The insulin levels in FEP patients were higher than in controls (g = 0.34, 95%CI: 0.19 – 0.49, p < 0.001), even considering only antipsychotic-naïve patients (g = 0.39, 95%CI: 0.12 – 0.66, p = 0.005). The severity of negative symptoms was positively associated with the effect size estimates (β = 0.08, 95%CI: 0.01 – 0.16, p = 0.030). Moreover, we found lower levels of leptin in antipsychotic-naïve FEP patients (g = -0.62, 95%CI: -1.11 – 0.12, p = 0.015). Impaired appetite regulation, in terms of elevated insulin levels and decreased leptin levels, occurs in early psychosis, before antipsychotic treatment. Hyperinsulinemia might be related to negative symptoms.
Articolo in rivista - Articolo scientifico
Insulin; Leptin; Metabolism; Obesity; Schizophrenia;
Insulin; Leptin; Metabolism; Obesity; Schizophrenia
English
2019
102
362
370
none
Misiak, B., Bartoli, F., Stramecki, F., Samochowiec, J., Lis, M., Kasznia, J., et al. (2019). Appetite regulating hormones in first-episode psychosis: A systematic review and meta-analysis. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 102, 362-370 [10.1016/j.neubiorev.2019.05.018].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/231734
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