Thromboxane A, has been implicated, as an important pathophysiological mediator, in vascular dii. We tested the effects of pretreatment with different doses of G 619, a dual thromboxane synthase inhibitor and thromboxane AZ receptor antagonist that showed to have positive effects in splanchnic artery occlusion shock (1), on levels of brain malonildialdehyde (a product of lipid peroxidation), mortality and hyperactivity following stroke-brain injury in the Mongolian gerbils. Brain ischemia/reperfusion injury was induced by 5 min of bilateral occlusion of common carotid arteries, a procedure which causes hippocampal lesions in the gerbils (2). G 619 (12.5,25 and 50 mg/kg/i.p.) administered 30 min before occlusion, significantly reduced brain malondialdehyde formation, mortality and hyperactivity following global cerebral ischemia. Data suggest that G 619 might be effective in improving ischemic cerebral damage.

Calapai, G., Campo, G., Marciano, M., Cilia, M., Mazzaglia, G., Rizzo, A., et al. (1992). EFFECTS OF G 619 ON CEREBRAL ISCHEMIA/REPERFUSION INJURY IN MONGOLIAN GERBILS. Intervento presentato a: 26° Congresso Nazionale della Società Italiana di Farmacologia, Napoli.

EFFECTS OF G 619 ON CEREBRAL ISCHEMIA/REPERFUSION INJURY IN MONGOLIAN GERBILS

Mazzaglia G;
1992

Abstract

Thromboxane A, has been implicated, as an important pathophysiological mediator, in vascular dii. We tested the effects of pretreatment with different doses of G 619, a dual thromboxane synthase inhibitor and thromboxane AZ receptor antagonist that showed to have positive effects in splanchnic artery occlusion shock (1), on levels of brain malonildialdehyde (a product of lipid peroxidation), mortality and hyperactivity following stroke-brain injury in the Mongolian gerbils. Brain ischemia/reperfusion injury was induced by 5 min of bilateral occlusion of common carotid arteries, a procedure which causes hippocampal lesions in the gerbils (2). G 619 (12.5,25 and 50 mg/kg/i.p.) administered 30 min before occlusion, significantly reduced brain malondialdehyde formation, mortality and hyperactivity following global cerebral ischemia. Data suggest that G 619 might be effective in improving ischemic cerebral damage.
No
poster + paper
Scientifica
Thromboxane; ischemia/reperfusion injury; animal models; G 619
English
26° Congresso Nazionale della Società Italiana di Farmacologia
Calapai, G., Campo, G., Marciano, M., Cilia, M., Mazzaglia, G., Rizzo, A., et al. (1992). EFFECTS OF G 619 ON CEREBRAL ISCHEMIA/REPERFUSION INJURY IN MONGOLIAN GERBILS. Intervento presentato a: 26° Congresso Nazionale della Società Italiana di Farmacologia, Napoli.
Calapai, G; Campo, G; Marciano, M; Cilia, M; Mazzaglia, G; Rizzo, A; Spignoli, G; Squadrito, F
File in questo prodotto:
File Dimensione Formato  
1992 Pharmacol Res.pdf

Solo gestori archivio

Dimensione 78.45 kB
Formato Adobe PDF
78.45 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/225277
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
Social impact