Intravenous (640 micrograms/kg) or intracerebroventricular (0.5 and 1 microgram) injection of Escherichia coli endotoxin (LPS) causes inhibition of water intake induced by 24 hour period of water deprivation in the rat. Tumor necrosis factor alpha (TNF-alpha; 20 and 40 ng/rat) given into the lateral cerebral ventricle (i.c.v.) causes effects similar to those observed after LPS. Cloricromene, given either intravenously (1 and 2 mg/kg) or i.c.v. (250 and 500 ng), abolished the antidipsogenic effect induced by LPS (administered both i.v. and i.c.v.). Cloricromene (2 mg/kg, i.v. or 500 ng/rat, i.c.v.), on the contrary, did not modify the antidipsogenic effects induced by TNF-alpha. These data indicate that peripherally injected cloricromene (as well as that i.c.v. injected) antagonizes the effects of mediators of LPS on sites regulating thirst and suggest that cloricromene's action may be due to inhibition of brain TNF-alpha formation induced by LPS.

Calapai, G., Mazzaglia, G., Marciano, M., Squadrito, F., Altavilla, D., Zingarelli, B., et al. (1992). Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF-alpha, in the rat. LIFE SCIENCES, 51(26), 2041-2048 [10.1016/0024-3205(92)90154-H].

Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF-alpha, in the rat

Mazzaglia G;
1992

Abstract

Intravenous (640 micrograms/kg) or intracerebroventricular (0.5 and 1 microgram) injection of Escherichia coli endotoxin (LPS) causes inhibition of water intake induced by 24 hour period of water deprivation in the rat. Tumor necrosis factor alpha (TNF-alpha; 20 and 40 ng/rat) given into the lateral cerebral ventricle (i.c.v.) causes effects similar to those observed after LPS. Cloricromene, given either intravenously (1 and 2 mg/kg) or i.c.v. (250 and 500 ng), abolished the antidipsogenic effect induced by LPS (administered both i.v. and i.c.v.). Cloricromene (2 mg/kg, i.v. or 500 ng/rat, i.c.v.), on the contrary, did not modify the antidipsogenic effects induced by TNF-alpha. These data indicate that peripherally injected cloricromene (as well as that i.c.v. injected) antagonizes the effects of mediators of LPS on sites regulating thirst and suggest that cloricromene's action may be due to inhibition of brain TNF-alpha formation induced by LPS.
Articolo in rivista - Articolo scientifico
Tumor-Necrosis-Factor; Inhibition; Drinking; Shock
English
2041
2048
8
Calapai, G., Mazzaglia, G., Marciano, M., Squadrito, F., Altavilla, D., Zingarelli, B., et al. (1992). Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF-alpha, in the rat. LIFE SCIENCES, 51(26), 2041-2048 [10.1016/0024-3205(92)90154-H].
Calapai, G; Mazzaglia, G; Marciano, M; Squadrito, F; Altavilla, D; Zingarelli, B; Prosdocimi, M; Caputi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/225254
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