Intravenous (640 micrograms/kg) or intracerebroventricular (0.5 and 1 microgram) injection of Escherichia coli endotoxin (LPS) causes inhibition of water intake induced by 24 hour period of water deprivation in the rat. Tumor necrosis factor alpha (TNF-alpha; 20 and 40 ng/rat) given into the lateral cerebral ventricle (i.c.v.) causes effects similar to those observed after LPS. Cloricromene, given either intravenously (1 and 2 mg/kg) or i.c.v. (250 and 500 ng), abolished the antidipsogenic effect induced by LPS (administered both i.v. and i.c.v.). Cloricromene (2 mg/kg, i.v. or 500 ng/rat, i.c.v.), on the contrary, did not modify the antidipsogenic effects induced by TNF-alpha. These data indicate that peripherally injected cloricromene (as well as that i.c.v. injected) antagonizes the effects of mediators of LPS on sites regulating thirst and suggest that cloricromene's action may be due to inhibition of brain TNF-alpha formation induced by LPS.

Calapai, G., Mazzaglia, G., Marciano, M., Squadrito, F., Altavilla, D., Zingarelli, B., et al. (1992). Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF-alpha, in the rat. LIFE SCIENCES, 51(26), 2041-2048 [10.1016/0024-3205(92)90154-H].

Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF-alpha, in the rat

Mazzaglia G;
1992

Abstract

Intravenous (640 micrograms/kg) or intracerebroventricular (0.5 and 1 microgram) injection of Escherichia coli endotoxin (LPS) causes inhibition of water intake induced by 24 hour period of water deprivation in the rat. Tumor necrosis factor alpha (TNF-alpha; 20 and 40 ng/rat) given into the lateral cerebral ventricle (i.c.v.) causes effects similar to those observed after LPS. Cloricromene, given either intravenously (1 and 2 mg/kg) or i.c.v. (250 and 500 ng), abolished the antidipsogenic effect induced by LPS (administered both i.v. and i.c.v.). Cloricromene (2 mg/kg, i.v. or 500 ng/rat, i.c.v.), on the contrary, did not modify the antidipsogenic effects induced by TNF-alpha. These data indicate that peripherally injected cloricromene (as well as that i.c.v. injected) antagonizes the effects of mediators of LPS on sites regulating thirst and suggest that cloricromene's action may be due to inhibition of brain TNF-alpha formation induced by LPS.
Articolo in rivista - Articolo scientifico
Tumor-Necrosis-Factor; Inhibition; Drinking; Shock
English
1992
51
26
2041
2048
reserved
Calapai, G., Mazzaglia, G., Marciano, M., Squadrito, F., Altavilla, D., Zingarelli, B., et al. (1992). Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF-alpha, in the rat. LIFE SCIENCES, 51(26), 2041-2048 [10.1016/0024-3205(92)90154-H].
File in questo prodotto:
File Dimensione Formato  
1992 Life Sci.pdf

Solo gestori archivio

Dimensione 682.97 kB
Formato Adobe PDF
682.97 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/225254
Citazioni
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 7
Social impact