Brain nitric oxide is involved in the mechanisms that regulate ingestive behavior. To test whether this compound plays a role in alcohol preference, we studied the effects of different doses of NG-nitro-L-arginine (L-NO arg), an inhibitor of nitric oxide synthase (NOS), on voluntary consumption of ethanol and on blood alcohol levels produced by a single intraperitoneal dose of alcohol in the rat. L-NO arg produced a significant and dose-dependent reduction of ethanol intake (P < 0.001) without influencing total fluid consumption or feeding behavior. L-NO arg did not influence the kinetics of alcohol. Our data show that inhibition of nitric oxide formation accompanies reduction of ethanol intake and suggest a possible role for nitric oxide in ethanol self-administration

Calapai, G., Mazzaglia, G., Sautebin, L., Costantino, G., Marciano, M., Cuzzocrea, S., et al. (1996). Inhibition of nitric oxide formation reduces voluntary ethanol consumption in the rat. PSYCHOPHARMACOLOGY, 125(4), 398-401 [10.1007/BF02246024].

Inhibition of nitric oxide formation reduces voluntary ethanol consumption in the rat

Mazzaglia G;
1996

Abstract

Brain nitric oxide is involved in the mechanisms that regulate ingestive behavior. To test whether this compound plays a role in alcohol preference, we studied the effects of different doses of NG-nitro-L-arginine (L-NO arg), an inhibitor of nitric oxide synthase (NOS), on voluntary consumption of ethanol and on blood alcohol levels produced by a single intraperitoneal dose of alcohol in the rat. L-NO arg produced a significant and dose-dependent reduction of ethanol intake (P < 0.001) without influencing total fluid consumption or feeding behavior. L-NO arg did not influence the kinetics of alcohol. Our data show that inhibition of nitric oxide formation accompanies reduction of ethanol intake and suggest a possible role for nitric oxide in ethanol self-administration
Articolo in rivista - Articolo scientifico
Scientifica
Alcohol; Alcohol self-administration; Alcohol intake; Ntric oxide; Brain
English
Calapai, G., Mazzaglia, G., Sautebin, L., Costantino, G., Marciano, M., Cuzzocrea, S., et al. (1996). Inhibition of nitric oxide formation reduces voluntary ethanol consumption in the rat. PSYCHOPHARMACOLOGY, 125(4), 398-401 [10.1007/BF02246024].
Calapai, G; Mazzaglia, G; Sautebin, L; Costantino, G; Marciano, M; Cuzzocrea, S; Di Rosa, M; Caputi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/225151
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