Aims. The aim of our study was to measure carotid intima-media thickness (cIMT) and risk factors associated with its development and progression, and to evaluate arterial wall characteristics through integrated backscatter analysis (IBS) in HIV patients. Methods. Perspective cohort study enrolling 44 HIV patients treated with antiretroviral drugs who underwent standard B Mode cIMT measurement and tissue characterization of carotid wall by means of dedicated software by acoustic densitometry, at time 0 and 2 years later. Major findings. Cross-sectional evaluation performed at baseline found that cIMT value correlated significantly with age (r - 0.42, p - 0.005) and systolic blood pressure (r - 0.31, p - 0.04). No correlation was found between cIMT and CD4, HIV-RNA, triglycerides or total cholesterol. There was no difference between the group with versus the group with no protease inhibitors treatment. cIMT progression during 2 years of observation was statistically significant (median, interquartile range [IQR]: 0.005, 0-0.031). No correlation was found between IBS and duration of disease and kind of therapy, whereas a significant association was found between cIMT and IBS (r = 0.33, p = 0.03). No noticeable changes of IBS were observed during 2 years observation. Conclusions. Classic risk factors greatly affect cIMT than time of HIV infection, duration of antiretroviral therapy exposure and use of protease inhibitors. IBS is a promising technique for the evaluation of arterial wall composition in HIV patients.

Giannattasio, C., Failla, M., Squillace, N., Dolara, A., Cesana, F., Sabbatini, F., et al. (2010). Ultrasonographic backscatter of the carotid artery wall in patients with HIV infection: a pilot study. BLOOD PRESSURE, 19(6), 344-350 [10.3109/08037051.2010.506997].

Ultrasonographic backscatter of the carotid artery wall in patients with HIV infection: a pilot study

GIANNATTASIO, CRISTINA
;
FACCHETTI, RITA LUCIA;GORI, ANDREA;MANCIA, GIUSEPPE
2010

Abstract

Aims. The aim of our study was to measure carotid intima-media thickness (cIMT) and risk factors associated with its development and progression, and to evaluate arterial wall characteristics through integrated backscatter analysis (IBS) in HIV patients. Methods. Perspective cohort study enrolling 44 HIV patients treated with antiretroviral drugs who underwent standard B Mode cIMT measurement and tissue characterization of carotid wall by means of dedicated software by acoustic densitometry, at time 0 and 2 years later. Major findings. Cross-sectional evaluation performed at baseline found that cIMT value correlated significantly with age (r - 0.42, p - 0.005) and systolic blood pressure (r - 0.31, p - 0.04). No correlation was found between cIMT and CD4, HIV-RNA, triglycerides or total cholesterol. There was no difference between the group with versus the group with no protease inhibitors treatment. cIMT progression during 2 years of observation was statistically significant (median, interquartile range [IQR]: 0.005, 0-0.031). No correlation was found between IBS and duration of disease and kind of therapy, whereas a significant association was found between cIMT and IBS (r = 0.33, p = 0.03). No noticeable changes of IBS were observed during 2 years observation. Conclusions. Classic risk factors greatly affect cIMT than time of HIV infection, duration of antiretroviral therapy exposure and use of protease inhibitors. IBS is a promising technique for the evaluation of arterial wall composition in HIV patients.
Articolo in rivista - Articolo scientifico
Scientifica
Atherosclerosis; Carotid Arteries; Male; Middle Aged; HIV Infections; Pilot Projects; Risk Factors; Humans; Cohort Studies; Prospective Studies; Disease Progression; Antiretroviral Therapy, Highly Active; Tunica Media; Adult; Tunica Intima;
English
Giannattasio, C., Failla, M., Squillace, N., Dolara, A., Cesana, F., Sabbatini, F., et al. (2010). Ultrasonographic backscatter of the carotid artery wall in patients with HIV infection: a pilot study. BLOOD PRESSURE, 19(6), 344-350 [10.3109/08037051.2010.506997].
Giannattasio, C; Failla, M; Squillace, N; Dolara, A; Cesana, F; Sabbatini, F; Bandera, A; Facchetti, R; Dozio, D; Gori, A; Mancia, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/22462
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