Oxygen fret radicals have been implicated in ischemia/reperfusion injury (1). We investigated the effects of pretreatment with IRFI-016, a new antioxidant drug, that proved to have beneficial effects in myocardial &hernia (2), on levels of cerebral malonildialdehyde (a product of lipid peroxidation), mortality and hyperactivity following brain ischemia/reperfusion injury in the Mongolian gerbils. Brain ischemia/reperfusion injury was induced by 5 mm of bilateral occlusion of common carotid arteries followed by reperfusion, a procedure which causes hippocampal lesions in the gerbils (3). IRF!I-016 (50, 100 and 200 mglkg/i.p.), administered 30 min before occlusion, significantly reduced cerebral malondialdehyde formation, mortality and hyperactivity following global cerebral ischemia and reperfusion. Data indicate that IRFI-016 might be effective in improving ischemic cerebral damage.

Marciano, M., Calapai, G., Campo, G., Mazzaglia, G., Cilia, M., Rizzo, A., et al. (1992). Irfi-016, a Selective Analogue of Vitamin E, Exerts Beneficial Effects on Cerebral Ischemia/Reperfusion Injury in Mongolian Gerbils. Intervento presentato a: 26° Congresso Nazionale della Società Italiana di Farmacologia, Napoli [10.1016/1043-6618(92)91064-N].

Irfi-016, a Selective Analogue of Vitamin E, Exerts Beneficial Effects on Cerebral Ischemia/Reperfusion Injury in Mongolian Gerbils

Mazzaglia G;
1992

Abstract

Oxygen fret radicals have been implicated in ischemia/reperfusion injury (1). We investigated the effects of pretreatment with IRFI-016, a new antioxidant drug, that proved to have beneficial effects in myocardial &hernia (2), on levels of cerebral malonildialdehyde (a product of lipid peroxidation), mortality and hyperactivity following brain ischemia/reperfusion injury in the Mongolian gerbils. Brain ischemia/reperfusion injury was induced by 5 mm of bilateral occlusion of common carotid arteries followed by reperfusion, a procedure which causes hippocampal lesions in the gerbils (3). IRF!I-016 (50, 100 and 200 mglkg/i.p.), administered 30 min before occlusion, significantly reduced cerebral malondialdehyde formation, mortality and hyperactivity following global cerebral ischemia and reperfusion. Data indicate that IRFI-016 might be effective in improving ischemic cerebral damage.
No
poster + paper
Scientifica
Vitamin E; Animal Models; Ischemia/Reperfusion
English
26° Congresso Nazionale della Società Italiana di Farmacologia
Marciano, M., Calapai, G., Campo, G., Mazzaglia, G., Cilia, M., Rizzo, A., et al. (1992). Irfi-016, a Selective Analogue of Vitamin E, Exerts Beneficial Effects on Cerebral Ischemia/Reperfusion Injury in Mongolian Gerbils. Intervento presentato a: 26° Congresso Nazionale della Società Italiana di Farmacologia, Napoli [10.1016/1043-6618(92)91064-N].
Marciano, M; Calapai, G; Campo, G; Mazzaglia, G; Cilia, M; Rizzo, A; Scuri, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/223737
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