Purpose To develop a mathematical model of oxygenation during venovenous extracorporeal membrane oxygenation (vv-ECMO). Material and methods Total oxygen consumption, cardiac output, blood flow, recirculation, intrapulmonary shunt, hemoglobin, natural lung, and membrane lung oxygen fractions were chosen as inputs. Content, partial pressure, and hemoglobin saturation of oxygen in arterial, venous, pulmonary, and extracorporeal blood were outputs. To assess accuracy and predictive power of the model, we retrospectively analyzed data of 25 vv-ECMO patients. We compiled 2 software (with numerical, 2D and 3D graphical outputs) to study the impact of each variable on oxygenation. Results The model showed high accuracy and predictive power. Raising blood flow and oxygen fraction to the membrane lung or reducing total oxygen consumption improves arterial and venous oxygenation, especially in severe cases; raising oxygen fraction to the natural lung improves oxygenation only in milder cases; raising hemoglobin always improves oxygenation, especially in the venous district; recirculation fraction severely impairs oxygenation. In severely ill patients, increasing cardiac output worsens arterial oxygenation but enhances venous oxygenation. Oxygen saturation of ECMO inlet is critical to evaluate the appropriateness of oxygen delivery. Conclusions The model with the software can be a useful teaching tool and a valuable decision-making aid for the management of hypoxic patients supported by vv-ECMO.

Zanella, A., Salerno, D., Scaravilli, V., Giani, M., Castagna, L., Magni, F., et al. (2016). A mathematical model of oxygenation during venovenous extracorporeal membrane oxygenation support. JOURNAL OF CRITICAL CARE, 36, 178-186 [10.1016/j.jcrc.2016.07.008].

A mathematical model of oxygenation during venovenous extracorporeal membrane oxygenation support

Zanella, A
;
Salerno, D;Scaravilli, V;Giani, M;Magni, F;Patroniti, N;Pesenti, A
2016

Abstract

Purpose To develop a mathematical model of oxygenation during venovenous extracorporeal membrane oxygenation (vv-ECMO). Material and methods Total oxygen consumption, cardiac output, blood flow, recirculation, intrapulmonary shunt, hemoglobin, natural lung, and membrane lung oxygen fractions were chosen as inputs. Content, partial pressure, and hemoglobin saturation of oxygen in arterial, venous, pulmonary, and extracorporeal blood were outputs. To assess accuracy and predictive power of the model, we retrospectively analyzed data of 25 vv-ECMO patients. We compiled 2 software (with numerical, 2D and 3D graphical outputs) to study the impact of each variable on oxygenation. Results The model showed high accuracy and predictive power. Raising blood flow and oxygen fraction to the membrane lung or reducing total oxygen consumption improves arterial and venous oxygenation, especially in severe cases; raising oxygen fraction to the natural lung improves oxygenation only in milder cases; raising hemoglobin always improves oxygenation, especially in the venous district; recirculation fraction severely impairs oxygenation. In severely ill patients, increasing cardiac output worsens arterial oxygenation but enhances venous oxygenation. Oxygen saturation of ECMO inlet is critical to evaluate the appropriateness of oxygen delivery. Conclusions The model with the software can be a useful teaching tool and a valuable decision-making aid for the management of hypoxic patients supported by vv-ECMO.
Articolo in rivista - Articolo scientifico
Blood circulation; Cardiac output; Extracorporeal circulation; Extracorporeal membrane oxygenation; Oxygen consumption; Theoretical models;
Blood circulation; Cardiac output; Extracorporeal circulation; Extracorporeal membrane oxygenation; Oxygen consumption; Theoretical models; Adult; Decision Support Techniques; Female; Hemodynamics; Humans; Hypoxia; Male; Middle Aged; Models, Biological; Models, Theoretical; Oximetry; Oxygen; Partial Pressure; Retrospective Studies; Software; Cardiac Output; Extracorporeal Membrane Oxygenation; Oxygen Consumption; Critical Care and Intensive Care Medicine
English
2016
178
186
9
Zanella, A., Salerno, D., Scaravilli, V., Giani, M., Castagna, L., Magni, F., et al. (2016). A mathematical model of oxygenation during venovenous extracorporeal membrane oxygenation support. JOURNAL OF CRITICAL CARE, 36, 178-186 [10.1016/j.jcrc.2016.07.008].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/223392
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