Avascular necrosis (AVN) is a disease due to the interruption of the blood supply to the bone. It is one of the most common and debilitating therapy-related sequelae of the antileukemic treatment and it may not be clinically recognized. Symptomatic AVN have been reported in 1-17% of children with acute lymphoblastic leukemia (ALL) during treatment or thereafter although an incidence of up to 72% of asymptomatic AVN has been detected with systematic screening by magnetic resonance imaging (MRI). In all cases AVN is related to ALL treatment and in particular to high-dose steroids. While the AVN of the hip is frequently reported in the literature, reports regarding AVN of the talus are lacking; moreover, there is little consensus about its incidence, diagnostic algorithm and treatment. Talus is an articular weight-bearing bone with over 60% of the surface covered by cartilage and a specific limited vascular supply. The aim of this article is to provide an up-to-date review about management of avascular necrosis of the talus highlighting the importance of early diagnosis based on ankle MRI imaging in pediatric patients affected with ALL.

Cossio, A., Bigoni, M., Lombardo, A., Graci, J., Borra, D., Balduzzi, A., et al. (2019). Avascular necrosis of the talus in pediatric acute lymphoblastic leukemia: Current concepts. MINERVA ORTOPEDICA E TRAUMATOLOGICA, 70(1), 32-39 [10.23736/S0394-3410.19.03908-0].

Avascular necrosis of the talus in pediatric acute lymphoblastic leukemia: Current concepts

Cossio, Andrea;Bigoni, Marco;Lombardo, Antonino S.
;
Graci, Jole;Balduzzi, Adriana;Brivio, Erica;Turati, Marco;Zatti, Giovanni
2019

Abstract

Avascular necrosis (AVN) is a disease due to the interruption of the blood supply to the bone. It is one of the most common and debilitating therapy-related sequelae of the antileukemic treatment and it may not be clinically recognized. Symptomatic AVN have been reported in 1-17% of children with acute lymphoblastic leukemia (ALL) during treatment or thereafter although an incidence of up to 72% of asymptomatic AVN has been detected with systematic screening by magnetic resonance imaging (MRI). In all cases AVN is related to ALL treatment and in particular to high-dose steroids. While the AVN of the hip is frequently reported in the literature, reports regarding AVN of the talus are lacking; moreover, there is little consensus about its incidence, diagnostic algorithm and treatment. Talus is an articular weight-bearing bone with over 60% of the surface covered by cartilage and a specific limited vascular supply. The aim of this article is to provide an up-to-date review about management of avascular necrosis of the talus highlighting the importance of early diagnosis based on ankle MRI imaging in pediatric patients affected with ALL.
Articolo in rivista - Articolo scientifico
Child; Osteonecrosis; Precursor cell lymphoblastic leukemia-lymphoma; Talus;
avascluar necrosis, leukemia, children
English
32
39
8
Cossio, A., Bigoni, M., Lombardo, A., Graci, J., Borra, D., Balduzzi, A., et al. (2019). Avascular necrosis of the talus in pediatric acute lymphoblastic leukemia: Current concepts. MINERVA ORTOPEDICA E TRAUMATOLOGICA, 70(1), 32-39 [10.23736/S0394-3410.19.03908-0].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/223141
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